NEAT & Physical Activity Assessment in the Elderly

描述（由申请人提供）： 体力活动消耗的能量是能量平衡和体重的重要组成部分。由于自由生活的人类进行的各种身体活动，获得人类身体活动的量或能量成本的准确测量是极其具有挑战性的。体力活动中消耗的能量包括有目的运动中消耗的能量和非运动活动产热（NEAT）中消耗的能量。后者比前者更难衡量。由于大多数美国人从事相对较少的有目的的体育活动，大部分能量消耗在体育活动将通过NEAT。NEAT在肌肉减少症的病理生理学中的作用尚不明确，尽管人们普遍认为身体活动随着年龄的增长而下降。这项建议的目的是首先询问老年人与年轻人相比是否确实减少了NEAT。其次，我们希望在老年人群中验证一种非侵入式传感器系统，即测量NEAT及其组件的身体活动监测系统（PAMS）。第三，如果PAMS是有效的，我们想探讨老年人NEAT的组成部分。因此，我们提出了三个假设：假设1：与年轻的非肥胖、久坐不动的健康受试者相比，老年人的NEAT降低。假设2：身体活动监测系统（PAMS）提供了老年人NEAT的有效估计。假设#3：与年轻的非肥胖、久坐、健康受试者相比，老年人中步行EE代表NEAT的较小组成部分。这些数据有可能帮助我们了解衰老对能量平衡、非运动性体力活动和流动性的影响。这些研究可能会指导我们设计新的策略来预防老年人的肌肉减少症和促进身体活动。

DESCRIPTION (provided by applicant): The energy expended in physical activity is an important component of energy balance and body weight. Because of the variety of physical activities that free-living humans undertake, it has been extremely challenging to obtain accurate measurements of either the amount or, energy cost of human physical activity. The energy expended in physical activity consists of energy expended in purposeful exercise and the energy expended in non-exercise activity thermogenesis (NEAT). The latter is even more difficult to measure than the former. Since most Americans engage in relatively little purposeful physical activity, the majority of energy expended in physical activity will be through NEAT. The role of NEAT in the pathophysiology of sarcopenia is poorly defined although it is widely recognized that physical activity declines with aging. The aims of this proposal are first, to ask if aging individuals indeed have decreased NEAT compared to young individuals. Second, we want to validate, in an older population, a non-invasive sensor system, the Physical Activity Monitoring System (PAMS) that measures NEAT and its components. Third, if PAMS is valid, we want to explore the components of NEAT in the elderly. Thus, we propose to address three hypotheses: Hypothesis #1: NEAT is decreased in older compared to younger non-obese, sedentary, healthy subjects. Hypothesis #2: The Physical Activity Monitoring System (PAMS) provides valid estimates of NEAT in the elderly. Hypothesis #3: Walking EE represents a lesser component of NEAT in older compared to younger nonobese, sedentary, healthy subjects. These data have the potential to help us understand the impact of aging on energy balance, nonexercise physical activity and mobility. These studies may potentially guide us to devise novel strategies to prevent sarcopenia and promote physical activity in the elderly.