Non exercise activity thermogenesis in rural and urban dwellers in Jamaica

描述(申请人提供)：在牙买加等许多发展中国家，日益繁荣的经济和工业化促进了人口、营养和流行病的转变。这些流行病学转变的特点是感染和营养不良导致的死亡率下降，肥胖症及其共病、高血压、糖尿病和动脉粥样硬化性血管疾病的流行迅速出现。人口肥胖增加的风险因素可能包括与体力活动相关的能量消耗减少。迫切需要有效、可行和可持续的干预措施，以改善发展中国家与肥胖有关的慢性病的流行。然而，实现预防的关键是详细了解不同人群中体重增加的途径。在这个项目中，我们建议测量牙买加城市居民和农村农业工人的体力活动能量消耗的一个主要组成部分--非运动活动生热。我们现在配备了身体活动监测系统(PAMS)来提供这种信息。通过它，我们计划解决牙买加城市居民与年龄和性别匹配的牙买加农村农业工人的三个假设：a)非运动活动产热(NEAT)减少，b)体力活动监测系统有效，c)NEAT的组成部分不同。这些研究结果将用于在牙买加以及可能在其他发展中国家制定预防肥胖症和相关慢性非传染性疾病的干预计划。这项研究将主要在牙买加西印度群岛大学与梅奥诊所的詹姆斯·莱文博士合作进行，作为国家卫生研究院赠款的延伸，丹麦卢比1-66270。

DESCRIPTION (provided by applicant): Increasing economic prosperity and industrialization have precipitated demographic, nutritional and epidemiologic transitions in many developing countries like Jamaica. These epidemiologic transitions are characterized by receding mortality from infection and malnutrition and the rapid emergence of an epidemic of obesity and its co-morbidities, hypertension, diabetes and atherosclerotic vascular disease. Risk factors for increasing obesity of populations are likely to include decreased physical activity related energy expenditure. There is an urgent need for effective, feasible and sustainable interventions to ameliorate the epidemic of chronic diseases associated with obesity in developing countries. Key to achieving prevention, however, is detailed knowledge of the pathways to weight gain in different populations. In this project, we propose to measure a major component of physical activity energy expenditure, Non-Exercise Activity Thermogenesis in urban dwellers and rural agricultural workers in Jamaica. We are now equipped with technology, the Physical Activity Monitoring System (PAMS) to provide such information. With it, we plan to address three hypotheses in urban dwellers from Jamaica compared with age and gender matched, rural agricultural workers in Jamaica; a) Non Exercise Activity Thermogenesis (NEAT) is decreased, b) the Physical Activity Monitoring System is valid and, c) the components of NEAT are different. These research findings will be used to develop intervention programs for the prevention of obesity and associated chronic non-communicable diseases in Jamaica and possibly in other developing countries. This research will be done primarily in Jamaica at the University of the West Indies in collaboration with Dr. James Levine at the Mayo Clinic, as an extension of NIH Grant, DK RO1-66270.