Non exercise activity thermogenesis in rural and urban dwellers in Jamaica

描述（由申请人提供）：在牙买加等许多发展中国家，日益增长的经济繁荣和工业化加速了人口、营养和流行病学的转变。这些流行病学转变的特点是感染和营养不良造成的死亡率下降，肥胖症及其合并症、高血压、糖尿病和动脉粥样硬化性血管疾病的流行迅速出现。人口肥胖增加的危险因素可能包括与体力活动相关的能量消耗减少。迫切需要采取有效、可行和可持续的干预措施，以减轻发展中国家与肥胖有关的慢性病的流行。然而，实现预防的关键是详细了解不同人群体重增加的途径。在这个项目中，我们建议测量牙买加城市居民和农村农业工人身体活动能量消耗的一个主要组成部分——非运动活动产热。我们现在配备了技术，即身体活动监测系统（PAMS）来提供这些信息。有了它，我们计划解决牙买加城市居民与年龄和性别匹配的三个假设，牙买加农村农业工人；a)非运动活动产热（NEAT）减少，b)身体活动监测系统有效，c) NEAT的组成部分不同。这些研究结果将用于制定干预方案，在牙买加并可能在其他发展中国家预防肥胖和相关的慢性非传染性疾病。这项研究将主要在牙买加西印度群岛大学进行，与梅奥诊所的James Levine博士合作，作为NIH补助金（DK RO1-66270）的延伸。

DESCRIPTION (provided by applicant): Increasing economic prosperity and industrialization have precipitated demographic, nutritional and epidemiologic transitions in many developing countries like Jamaica. These epidemiologic transitions are characterized by receding mortality from infection and malnutrition and the rapid emergence of an epidemic of obesity and its co-morbidities, hypertension, diabetes and atherosclerotic vascular disease. Risk factors for increasing obesity of populations are likely to include decreased physical activity related energy expenditure. There is an urgent need for effective, feasible and sustainable interventions to ameliorate the epidemic of chronic diseases associated with obesity in developing countries. Key to achieving prevention, however, is detailed knowledge of the pathways to weight gain in different populations. In this project, we propose to measure a major component of physical activity energy expenditure, Non-Exercise Activity Thermogenesis in urban dwellers and rural agricultural workers in Jamaica. We are now equipped with technology, the Physical Activity Monitoring System (PAMS) to provide such information. With it, we plan to address three hypotheses in urban dwellers from Jamaica compared with age and gender matched, rural agricultural workers in Jamaica; a) Non Exercise Activity Thermogenesis (NEAT) is decreased, b) the Physical Activity Monitoring System is valid and, c) the components of NEAT are different. These research findings will be used to develop intervention programs for the prevention of obesity and associated chronic non-communicable diseases in Jamaica and possibly in other developing countries. This research will be done primarily in Jamaica at the University of the West Indies in collaboration with Dr. James Levine at the Mayo Clinic, as an extension of NIH Grant, DK RO1-66270.