Bioengineering Approaches to Energy Balance and Obesity

描述（由申请人提供）：人们普遍认为久坐不利于国民健康。扭转久坐不动的解决方案包括设计和传播现实世界的解决方案，以促进全天的身体活动，帮助那些想要减肥、改善血糖、血脂和血压的人。Gruve是一种新颖、便携（30克）、价格低廉、无需电线、适应性强的技术，可用于测量成人和儿童的身体活动和身体姿势。我们展示了从先进的原型中获得的初步数据，这些数据证明了我们生产The Gruve的能力。这项提议的目的是设计一个精确、精密、坚固的可批量生产的电子平台，名为The Gruve，可以测量自由生活的人的身体活动和姿势。我们的假设是，The Gruve是一种准确、精确和坚固的设备，用于测量自由生活人群的身体活动和姿势。在这个应用程序的第一阶段：我们计划：-利用十年的研究开发加速度计为基础的设备，建立格鲁夫；一个有吸引力的，用户友好的设备，用于测量和促进身体活动。-将The Gruve与商业网络平台集成，Muve已在14家公司进行了开发、测试和部署。-在实验室环境中对双标水进行测试和验证。-将Gruve集成解决方案部署到来自Muve已经运营的五个商业账户的150人。Gruve解决方案是为可伸缩性而设计的。此外，我们已经建立了一个全国性的营销策略，并有企业客户准备测试一个包装的Gruve解决方案。在此申请的第二阶段：我们建议：- 1：在第一年将Gruve解决方案扩大到10家公司，在第二年扩大到40家公司。- 2：发展Gruve-Junior；为学校提供一个可扩展的活动推广平台- 3：向个人（成人和儿童）部署Gruve解决方案，他们希望购买设备并将基于web的解决方案集成到他们的日常生活中。我们建议，The Gruve将是一个适应性强、简单、准确和精密的电子平台，用于测量人类的一系列身体活动。当与格鲁夫解决方案的其他元素相结合时，我们希望为数百万渴望它的成年人和儿童提供活动，减肥和改善健康。

DESCRIPTION (provided by applicant): It is uniformly recognized that sedentariness - the sitting disease - is bad for the health of the nation. The solution to reversing sedentariness involves devising and disseminating real-world solutions to promote day-long physical activity and help people who want to, to lose weight and improve their blood glucose, lipids and blood pressure. The Gruve is a novel, portable (30 grams), inexpensive, wire-free, highly adaptable technology that can be used to measure physical activities and body posture in adults and children. We present preliminary data from prototypes of progressing sophistication that attest to our capability to produce The Gruve. The aim of this proposal is to devise an accurate, precise and robust mass-production ready electronic platform called, The Gruve that can measure physical activity and posture in free-living people. Our hypothesis is that The Gruve is an accurate, precise and robust device for measuring physical activity and posture in free-living people. In Phase 1 of this application: We plan to: - Leverage a decade of research in developing accelerometer based devices, to build The Gruve; an attractive, user-friendly device for measuring and promoting physical activity. - Integrate The Gruve with a commercial web-based platform, Muve has developed, tested and deployed in 14 companies. - Test and validate The Gruve against doubly labeled water in the laboratory setting. - Deploy The Gruve integrated solution into 150 people from five commercial accounts the Muve already operates in. The Gruve solution has been devised for scalability. Moreover we have established a nationwide marketing strategy and have corporate accounts prepared to beta-test a packaged Gruve Solution. In Phase 2 of this application: We propose to: - 1: Scale-up The Gruve Solution to 10 companies within Year 1 and forty companies in Year 2. - 2: Develop Gruve-Junior; a scalable activity promoting platform for schools - 3: Deploy The Gruve Solution to individuals (adults & children) who wish to purchase the device and the integrated The Gruve web-based solution into their daily lives. We propose that The Gruve will be an adaptable, simple, accurate and precise electronic platform to measure a range of physical activities in humans. When combined with the other elements of The Gruve Solution, we hope to offer activity, weight loss and improved health to millions of adults and children who desire it. PUBLIC HEALTH RELEVANCE: Physical activity is known to be important in a variety of diseases such as cancer, high blood pressure, cholesterol problems, and diabetes. Physical activity is important tool in obesity and the frailty of ageing. A major problem in improve physical activity is the lack of scalable and effective solutions. We have a decade-long experience in designing valid research-grade tools for measuring physical activity. In this proposal we describe the design and validation of an ideal platform technology for measuring physical activity in free-living people called, The Gruve. The objective of this program is to develop The Gruve Solution; a commercial scalable solution for weight loss that integrates micro- electronics, behavioral therapy, web-based data presentation & social networking to promote physical activity, weight loss and health.