Bioengineering Approaches to Energy Balance and Obesity

描述（由申请人提供）：人们一致认为久坐-坐着的疾病-对国家的健康有害。 扭转久坐不动的解决方案涉及设计和传播现实世界的解决方案，以促进全天的身体活动，并帮助那些想要减肥和改善血糖，血脂和血压的人。 Gruve是一种新颖、便携（30克）、廉价、无线、适应性强的技术，可用于测量成人和儿童的身体活动和身体姿势。 我们目前的初步数据，从原型的先进性，证明了我们的能力，生产的格鲁夫。 该提案的目的是设计一个准确，精确和强大的大规模生产准备电子平台，称为Gruve，可以测量自由生活的人的身体活动和姿势。 我们的假设是，Gruve是一种准确，精确和强大的设备，用于测量自由生活的人的身体活动和姿势。 在本申请的第一阶段：我们计划： - 利用十年来在开发基于加速度计的设备方面的研究， 建立Gruve;一个有吸引力的，用户友好的测量和促进设备 体力活动。 - 将The Gruve与基于网络的商业平台相集成，Muve 在14家公司开发、测试和部署。 - 在实验室中测试和验证Gruve对双标记水的作用 设置. - 将Gruve集成解决方案部署到来自五个商业 穆夫已经在运作的账户 Gruve解决方案是为可扩展性而设计的。 此外，我们已经建立了一个全国性的营销战略，并有企业客户准备测试一个打包的Gruve解决方案。 在本申请的第2阶段：我们建议： - 一曰： 在第一年和第四十年内将Gruve解决方案扩展到10家公司 公司在第二年。 - 第二章： 开发Gruve-Junior;一个可扩展的学校活动推广平台 - 第三章： 将Gruve解决方案部署给希望 购买设备，并将基于网络的集成解决方案集成到他们的 日常生活 我们建议Gruve将是一个适应性强，简单，准确和精确的电子平台，以测量人类的一系列身体活动。 当与Gruve Solution的其他元素相结合时，我们希望为数百万渴望运动、减肥和改善健康的成年人和儿童提供运动、减肥和改善健康的服务。 公共卫生相关性：众所周知，身体活动对各种疾病都很重要，如癌症、高血压、胆固醇问题和糖尿病。 身体活动是肥胖和衰老的重要工具。 改善身体活动的一个主要问题是缺乏可扩展和有效的解决方案。 我们在设计用于测量身体活动的有效研究级工具方面拥有长达十年的经验。 在这个提案中，我们描述了一个理想的平台技术的设计和验证，用于测量自由生活的人的身体活动，称为Gruve。 该计划的目标是开发Gruve解决方案;一个商业可扩展的减肥解决方案，集成了微电子，行为治疗，基于网络的数据展示和社交网络，以促进体育活动，减肥和健康。

DESCRIPTION (provided by applicant): It is uniformly recognized that sedentariness - the sitting disease - is bad for the health of the nation. The solution to reversing sedentariness involves devising and disseminating real-world solutions to promote day-long physical activity and help people who want to, to lose weight and improve their blood glucose, lipids and blood pressure. The Gruve is a novel, portable (30 grams), inexpensive, wire-free, highly adaptable technology that can be used to measure physical activities and body posture in adults and children. We present preliminary data from prototypes of progressing sophistication that attest to our capability to produce The Gruve. The aim of this proposal is to devise an accurate, precise and robust mass-production ready electronic platform called, The Gruve that can measure physical activity and posture in free-living people. Our hypothesis is that The Gruve is an accurate, precise and robust device for measuring physical activity and posture in free-living people. In Phase 1 of this application: We plan to: - Leverage a decade of research in developing accelerometer based devices, to build The Gruve; an attractive, user-friendly device for measuring and promoting physical activity. - Integrate The Gruve with a commercial web-based platform, Muve has developed, tested and deployed in 14 companies. - Test and validate The Gruve against doubly labeled water in the laboratory setting. - Deploy The Gruve integrated solution into 150 people from five commercial accounts the Muve already operates in. The Gruve solution has been devised for scalability. Moreover we have established a nationwide marketing strategy and have corporate accounts prepared to beta-test a packaged Gruve Solution. In Phase 2 of this application: We propose to: - 1: Scale-up The Gruve Solution to 10 companies within Year 1 and forty companies in Year 2. - 2: Develop Gruve-Junior; a scalable activity promoting platform for schools - 3: Deploy The Gruve Solution to individuals (adults & children) who wish to purchase the device and the integrated The Gruve web-based solution into their daily lives. We propose that The Gruve will be an adaptable, simple, accurate and precise electronic platform to measure a range of physical activities in humans. When combined with the other elements of The Gruve Solution, we hope to offer activity, weight loss and improved health to millions of adults and children who desire it. PUBLIC HEALTH RELEVANCE: Physical activity is known to be important in a variety of diseases such as cancer, high blood pressure, cholesterol problems, and diabetes. Physical activity is important tool in obesity and the frailty of ageing. A major problem in improve physical activity is the lack of scalable and effective solutions. We have a decade-long experience in designing valid research-grade tools for measuring physical activity. In this proposal we describe the design and validation of an ideal platform technology for measuring physical activity in free-living people called, The Gruve. The objective of this program is to develop The Gruve Solution; a commercial scalable solution for weight loss that integrates micro- electronics, behavioral therapy, web-based data presentation & social networking to promote physical activity, weight loss and health.