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Bioengineering Approaches to Energy Balance and Obesity

能量平衡和肥胖的生物工程方法

基本信息

批准号：
8825626
负责人：
JAMES A LEVINE
金额：
$ 8.32万
依托单位：
GRUVE TECHNOLOGIES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-05-01 至 2014-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8825626
关键词：
Bioengineering Approaches Energy Balance Obesity

项目摘要

DESCRIPTION (provided by applicant): It is uniformly recognized that sedentariness - the sitting disease - is bad for the health of the nation. The solution to reversing sedentariness involves devising and disseminating real-world solutions to promote day-long physical activity and help people who want to, to lose weight and improve their blood glucose, lipids and blood pressure. The Gruve is a novel, portable (30 grams), inexpensive, wire-free, highly adaptable technology that can be used to measure physical activities and body posture in adults and children. We present preliminary data from prototypes of progressing sophistication that attest to our capability to produce The Gruve. The aim of this proposal is to devise an accurate, precise and robust mass-production ready electronic platform called, The Gruve that can measure physical activity and posture in free-living people. Our hypothesis is that The Gruve is an accurate, precise and robust device for measuring physical activity and posture in free-living people. In Phase 1 of this application: We plan to: - Leverage a decade of research in developing accelerometer based devices, to build The Gruve; an attractive, user-friendly device for measuring and promoting physical activity. - Integrate The Gruve with a commercial web-based platform, Muve has developed, tested and deployed in 14 companies. - Test and validate The Gruve against doubly labeled water in the laboratory setting. - Deploy The Gruve integrated solution into 150 people from five commercial accounts the Muve already operates in. The Gruve solution has been devised for scalability. Moreover we have established a nationwide marketing strategy and have corporate accounts prepared to beta-test a packaged Gruve Solution. In Phase 2 of this application: We propose to: - 1: Scale-up The Gruve Solution to 10 companies within Year 1 and forty companies in Year 2. - 2: Develop Gruve-Junior; a scalable activity promoting platform for schools - 3: Deploy The Gruve Solution to individuals (adults & children) who wish to purchase the device and the integrated The Gruve web-based solution into their daily lives. We propose that The Gruve will be an adaptable, simple, accurate and precise electronic platform to measure a range of physical activities in humans. When combined with the other elements of The Gruve Solution, we hope to offer activity, weight loss and improved health to millions of adults and children who desire it. PUBLIC HEALTH RELEVANCE: Physical activity is known to be important in a variety of diseases such as cancer, high blood pressure, cholesterol problems, and diabetes. Physical activity is important tool in obesity and the frailty of ageing. A major problem in improve physical activity is the lack of scalable and effective solutions. We have a decade-long experience in designing valid research-grade tools for measuring physical activity. In this proposal we describe the design and validation of an ideal platform technology for measuring physical activity in free-living people called, The Gruve. The objective of this program is to develop The Gruve Solution; a commercial scalable solution for weight loss that integrates micro- electronics, behavioral therapy, web-based data presentation & social networking to promote physical activity, weight loss and health.

描述（由申请人提供）：人们一致认为久坐——久坐疾病——不利于国民健康。扭转久坐习惯的解决方案包括设计和传播现实世界的解决方案，以促进全天的身体活动，并帮助那些想要减肥并改善血糖、血脂和血压的人。 Gruve 是一种新颖、便携（30 克）、廉价、无线、适应性强的技术，可用于测量成人和儿童的身体活动和身体姿势。我们提供了来自日益复杂的原型的初步数据，证明了我们生产 The Gruve 的能力。该提案的目的是设计一个准确、精确且强大的可大规模生产的电子平台，名为 Gruve，可以测量自由生活的人的身体活动和姿势。我们的假设是，Gruve 是一种准确、精确且强大的设备，用于测量自由生活的人的身体活动和姿势。在此应用的第一阶段：我们计划： - 利用十年来开发基于加速度计的设备的研究成果，构建 The Gruve；一种有吸引力的、用户友好的设备，用于测量和促进身体活动。 - 将 Gruve 与基于网络的商业平台集成，Muve 已在 14 家公司中进行开发、测试和部署。 - 在实验室环境中针对双标签水测试和验证 Gruve。 - 将 Gruve 集成解决方案部署到 Muve 已运营的 5 个商业帐户的 150 人中。Gruve 解决方案专为可扩展性而设计。此外，我们还制定了全国性的营销策略，并让企业客户准备好对打包的 Gruve 解决方案进行 Beta 测试。在此应用程序的第 2 阶段：我们建议： - 1：在第 1 年将 Gruve 解决方案扩大到 10 家公司，在第 2 年扩大到 40 家公司。 - 2：开发 Gruve-Junior；面向学校的可扩展活动推广平台 - 3：向希望购买设备并将基于 Web 的集成 The Gruve 解决方案融入日常生活的个人（成人和儿童）部署 Gruve 解决方案。我们建议 Gruve 将成为一个适应性强、简单、准确且精确的电子平台，用于测量人类的一系列身体活动。当与 Gruve 解决方案的其他要素相结合时，我们希望为数百万渴望的成人和儿童提供活动、减肥和改善健康的服务。公共健康相关性：众所周知，体力活动对于癌症、高血压、胆固醇问题和糖尿病等多种疾病很重要。体力活动是治疗肥胖和衰老衰弱的重要手段。改善身体活动的一个主要问题是缺乏可扩展且有效的解决方案。我们在设计用于测量身体活动的有效研究级工具方面拥有长达十年的经验。在本提案中，我们描述了一种理想的平台技术的设计和验证，该技术用于测量自由生活的人的身体活动，称为 Gruve。该计划的目标是开发 Gruve 解决方案；一种商业可扩展的减肥解决方案，集成了微电子、行为疗法、基于网络的数据呈现和社交网络，以促进身体活动、减肥和健康。