Pediatric Sleep Research Program

儿科睡眠研究计划

• 批准号: 6955952
• 负责人: Raouf S. Amin
• 金额: $ 14.66万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6955952
• 关键词: baroreceptors; baroreflex; blood pressure; cardiovascular disorder; clinical research; echocardiography; heart rate; heart ventricle; human morbidity; human subject; longitudinal human study; middle childhood (6-11); patient oriented research; sensory neuropathy; sleep apnea; wakefulness

DESCRIPTION (provided by applicant): Immediate Goals: To examine the cardiovascular morbidity in children with obstructive sleep apnea (OSA). Career Development Goals: To provide sufficient time to develop a research training program in pediatric sleep medicine and build on the current patient-oriented research. Research Project: The project will test the hypothesis that children with OSA have baroreceptor dysfunction, which correlates with BP abnormalities, which in turn predict end organ injury in the form of an increase in left ventricular mass. The goal is to examine in children (1) the interaction between OSA and baroreflex dysfunction, (2) the relation of OSA severity and baroreflex dysfunction to abnormalities in blood pressure control during wakefulness and sleep, (3) the association of the diminished baroreflex gain and impaired blood pressure control with an index of end organ damage, the left ventricular mass index, and (4) whether effective treatment of OSA results in significant improvement in baroreceptor function, blood pressure control and a decrease in left ventricular mass index. We will accomplish these aims by studying 7-13 year-old children with OSA and a matched group of normal children in a cross-sectional design. Baroreceptor function, 24-hour ambulatory blood pressure and left ventricular mass index will be studied. Baroreceptor function will be measured by non-invasive techniques based on combined computer analysis of heart rate and blood pressure measured by portapres. 24-hour ambulatory blood pressure will be measured by a spacelab monitor, and left ventricular mass index will be measured by direct M-mode echocardiogram. In a longitudinal study, the effect of adequate treatment of OSA on baroreceptor function, daytime and nocturnal blood pressure and left ventricular mass index will be examined. A cohort of children with OSA and matched controls will be followed for a period of 12 months after treatment. (End of Abstract)

描述(由申请人提供)： 近期目标：研究阻塞性睡眠呼吸暂停(OSA)儿童心血管疾病的发病率。职业发展目标：提供充足的时间开发儿科睡眠医学的研究培训计划，并在当前以患者为导向的研究基础上再接再厉。研究项目：该项目将检验以下假设：患有阻塞性睡眠呼吸暂停综合征的儿童存在压力感受器功能障碍，这与血压异常相关，而血压异常反过来又以左心室质量增加的形式预测终末器官损伤。我们的目标是在儿童中研究(1)阻塞性睡眠呼吸暂停和压力反射功能障碍之间的相互作用。 (2)OSA严重程度和压力反射障碍与清醒和睡眠时血压控制异常的关系；(3)压力反射增益减少和血压控制受损与终末器官损害指数和左心室重量指数的关系；(4)OSA的有效治疗是否导致压力感受器功能、血压控制和左心室重量指数下降的显著改善。我们将通过横断面设计研究7-13岁阻塞性睡眠呼吸暂停儿童和一组匹配的正常儿童来实现这些目标。将研究压力感受器功能、24小时动态血压和左心室重量指数。压力感受器功能将通过非侵入性技术进行测量，该技术基于Porapres测量的心率和血压的联合计算机分析。24小时动态血压将由Space Lab监护仪测量，左心室质量指数将由直接M型超声心动图测量。在一项纵向研究中，将检测OSA适当治疗对压力感受器功能、昼夜血压和左心室重量指数的影响。一组患有阻塞性睡眠呼吸暂停综合征的儿童和匹配的对照组儿童将在治疗后接受为期12个月的跟踪调查。(摘要结束)