MidCareer Investigator Award-Patient-Oriented Research

描述（由申请人提供）： 突破，突破：情绪障碍研究战略计划呼吁进行跨学科培训，以提高基于社区的研究能力，采用不同的理论方法，了解什么样的治疗或服务对谁有效，在什么情况下，以及为什么。 混合的理论方法的任务是特别相关的设计服务的异质性的概念，疾病和治疗，偏好的护理，并对治疗的期望，发生在初级保健设置之间的供应商，患者，家庭和社区。 与此同时，NIH主任的临床研究报告小组指出，致力于以病人为导向的研究的医生科学家的短缺对所有美国人的健康产生了严重后果。 因此，本申请的NIMH职业中期研究者奖在以患者为导向的 研究（K24）寻求对一名致力于以病人为导向的研究事业的家庭医生的支持，以开展具有公共卫生意义的研究，并指导其他人进行初级保健和心理健康。 该申请是基于对我作为临床研究者的优势以及我作为临床研究者职业生涯早期导师的角色的仔细考虑，并具有以下目标： (1)继续吸引、鼓励和指导初级临床研究人员在初级卫生保健环境中从事与精神障碍相关的高质量实践研究;（2）建立基础设施支持，鼓励和促进初级临床研究人员在家庭医学和精神病学等学科的职业生涯; (3)促进制定混合方法（定量和定性方法），以设计和评价侧重于初级卫生保健环境的心理健康干预措施; (4)领导一个跨学科的团队，设计，实施，评估和传播创新的干预措施，为抑郁症和其他精神疾病的初级保健患者。 这一K24应用的概念框架和活动基于与初级卫生保健中的心理健康干预措施相关的研究和职业发展的几项原则;即：（1）需要让患者和提供者参与干预措施的制定;（2）使用混合模型设计和评估干预措施;以及（3）需要发展基础设施，以持续研究“真实的世界”背景下的干预措施。

DESCRIPTION (provided by applicant): Breaking Ground, Breaking Through: The Strategic Plan for Mood Disorders Research called for interdisciplinary training to increase capacity for community-based research employing different theoretical approaches that are needed to understand what treatments or services are effective for whom, under what circumstances, and why. The task of blending theoretical approaches is particularly relevant to designing services given the heterogeneity in concepts of illness and treatment, preferences for care, and expectations about treatment that occur in primary care settings among providers, patients, families, and communities. At the same time, the NIH Director's Panel on Clinical Research Report pointed out that a shortage of physician-scientists committed to a career in patient-oriented research has serious consequences for the health of all Americans. Accordingly, this application for an NIMH Midcareer Investigator Award in Patient-Oriented Research (K24) seeks support for a family physician devoted to a career in patient-oriented research to carry out research of public health significance and to mentor others in primary health care and mental health. The application is based on careful consideration of my strengths as a clinician-investigator and the role I play as a mentor to clinician-investigators early in their career, and has the following goals: (1) to continue to attract, encourage, and mentor junior clinician-investigators to pursue high quality practice-based research related to mental disturbances in the primary health care setting; (2) to build infrastructure support that will encourage and facilitate the careers of junior clinician-investigators in disciplines such as Family Medicine and Psychiatry; (3) to contribute to the development of mixed methodology (quantitative and qualitative methods) for the design and evaluation of mental health interventions focused on primary health care settings; and, (4) to lead an interdisciplinary team that designs, implements, evaluates, and disseminates innovative interventions for depression and other psychiatric disturbances among primary care patients. The conceptual framework and activities of this K24 application rest on several principles for research and career development related to mental health interventions in primary health care; namely: (1) the need to involve the patients and providers in development of interventions; (2) the use of mixed models for design and evaluation of interventions; and (3) the need for infrastructure development for sustained research on interventions in "real world" settings.