MidCareer Investigator Award-Patient-Oriented Research

描述（由申请人提供）：突破性进展，突破：情绪障碍研究战略计划要求进行跨学科培训，以提高以社区为基础的研究能力，采用不同的理论方法，了解哪些治疗或服务对谁有效，在什么情况下有效，以及为什么有效。考虑到疾病和治疗概念的异质性、对护理的偏好以及提供者、患者、家庭和社区对初级保健环境中治疗的期望，混合理论方法的任务与设计服务特别相关。与此同时，美国国立卫生研究院临床研究报告主任小组指出，致力于以病人为导向的研究事业的医生科学家的短缺对所有美国人的健康造成了严重后果。因此，本申请以患者为导向的NIMH职业中期研究者奖

DESCRIPTION (provided by applicant): Breaking Ground, Breaking Through: The Strategic Plan for Mood Disorders Research called for interdisciplinary training to increase capacity for community-based research employing different theoretical approaches that are needed to understand what treatments or services are effective for whom, under what circumstances, and why. The task of blending theoretical approaches is particularly relevant to designing services given the heterogeneity in concepts of illness and treatment, preferences for care, and expectations about treatment that occur in primary care settings among providers, patients, families, and communities. At the same time, the NIH Director's Panel on Clinical Research Report pointed out that a shortage of physician-scientists committed to a career in patient-oriented research has serious consequences for the health of all Americans. Accordingly, this application for an NIMH Midcareer Investigator Award in Patient-Oriented Research (K24) seeks support for a family physician devoted to a career in patient-oriented research to carry out research of public health significance and to mentor others in primary health care and mental health. The application is based on careful consideration of my strengths as a clinician-investigator and the role I play as a mentor to clinician-investigators early in their career, and has the following goals: (1) to continue to attract, encourage, and mentor junior clinician-investigators to pursue high quality practice-based research related to mental disturbances in the primary health care setting; (2) to build infrastructure support that will encourage and facilitate the careers of junior clinician-investigators in disciplines such as Family Medicine and Psychiatry; (3) to contribute to the development of mixed methodology (quantitative and qualitative methods) for the design and evaluation of mental health interventions focused on primary health care settings; and, (4) to lead an interdisciplinary team that designs, implements, evaluates, and disseminates innovative interventions for depression and other psychiatric disturbances among primary care patients. The conceptual framework and activities of this K24 application rest on several principles for research and career development related to mental health interventions in primary health care; namely: (1) the need to involve the patients and providers in development of interventions; (2) the use of mixed models for design and evaluation of interventions; and (3) the need for infrastructure development for sustained research on interventions in "real world" settings.