Clinical Research in Eating Disorders and Obesity

饮食失调和肥胖的临床研究

• 批准号: 6878089
• 负责人: Denise Ella Wilfley
• 金额: $ 10.52万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6878089
• 关键词: behavior therapy; behavioral /social science research tag; binge eating disorder; clinical research; comorbidity; disease /disorder etiology; disease /disorder prevention /control; disease /disorder proneness /risk; human subject; obesity; patient oriented research

DESCRIPTION (provided by applicant): The clinical and public health significance of eating disorders and obesity are well-documented, yet these problems are known to be resistant to treatment. This application is a request for an NIMH mid-career Investigator Award in Patient Oriented Research (K24) in order to relieve me from clinical, administrative, and teaching duties, to ensure 50% protected time for mentoring activities and patient-oriented research in the fields of eating disorders and obesity. This application will focus on an expansion of my research in intervention and prevention of eating disorders and obesity, areas in which I currently have three ongoing NIH-funded studies: "Effectiveness of Psychological treatments for BED" (R01 MH64153), "Interventions to Reduce Eating Disorder Risk Factors" (R01 MH60453), and Childhood Obesity: A Maintenance Approach" (R01 HD36904). These grants focus on, respectively: the long-term effectiveness of three distinct treatments for binge eating disorder (BED); the evaluation of an Internet program designed to reduce risk factors for and incidence of eating disorders; and the efficacy of two family-based treatments intended to improve long-term maintenance of weight loss in children. My overarching goals during the award period and in the long- term are: 1) to continue identifying and developing efficacious treatments for eating disorders and obesity; 2) to apply concepts and methods from basic behavioral science to the study of eating disorders and obesity in order to improve and refine treatments; 3) to clarify the diagnostic status of BED; 4) to investigate the role of familial and social factors in the etiology, prevention, and treatment of eating disorders and obesity; 5) to develop early intervention and prevention strategies aimed at preventing comorbidity, relapse, and disability in eating disorders and obesity; 6) to identify risk and protective factors for co-occurring illnesses, with particular attention to the links between eating disorders and obesity; and 7) to increase my training and mentoring of future clinical scientists, an area where I have already demonstrated strong commitment. I plan to build on my strengths by acquiring expertise in advanced research designs and methods; translational research; eating behavior, development, and psychopathology in children and adolescents; and metabolic processes and precise assessments of energy intake and expenditure. Becoming more knowledgeable in these areas will allow me to perform innovative research and provide enhanced opportunities for clinical researchers under my tutelage. Given the high morbidity and mortality associated with eating disorders and obesity, a continued refinement of treatment approaches and focus on early intervention and prevention is required to augment the rates of successful treatment responders and decrease the incidence of eating disorders and obesity.

描述（由申请人提供）：进食障碍和肥胖症的临床和公共卫生意义已得到充分证明，但已知这些问题对治疗具有抗药性。此应用程序是一个NIMH的职业中期研究者奖在以患者为导向的研究（K24）的要求，以减轻我从临床，行政和教学职责，以确保50%的指导活动和以患者为导向的研究在饮食失调和肥胖领域的保护时间。 该申请将重点扩展我在饮食失调和肥胖干预和预防方面的研究，在这些领域我目前正在进行三项NIH资助的研究：“床上心理治疗的有效性”（R 01 MH 64153）、“减少进食障碍风险因素的干预措施”（R 01 MH 60453）和"儿童肥胖：维持方法”（R 01 HD 36904）。这些赠款分别侧重于：三种不同的治疗暴饮暴食症（BED）的长期有效性;旨在减少饮食失调风险因素和发病率的互联网计划的评估;以及两种旨在改善儿童长期维持减肥的家庭治疗的疗效。我在获奖期间和长期的总体目标是：1）继续确定和开发有效的治疗饮食失调和肥胖症的方法; 2）将基础行为科学的概念和方法应用于饮食失调和肥胖症的研究，以改善和完善治疗方法; 3）澄清BED的诊断状态;（4）调查家庭和社会因素在饮食失调和肥胖的病因、预防和治疗中的作用;（5）制定旨在预防饮食失调和肥胖的合并症、复发和残疾的早期干预和预防策略; 6）确定并发疾病的风险和保护因素，特别注意饮食失调和肥胖之间的联系;和7）增加我对未来临床科学家的培训和指导，这是我已经表现出坚定承诺的领域。我计划通过获得先进的研究设计和方法的专业知识来建立我的优势;转化研究;儿童和青少年的饮食行为，发育和精神病理学;代谢过程和能量摄入和支出的精确评估。在这些领域变得更有知识将使我能够进行创新研究，并为我指导下的临床研究人员提供更多的机会。鉴于与进食障碍和肥胖症相关的高发病率和死亡率，需要继续完善治疗方法并注重早期干预和预防，以提高成功治疗应答者的比率并降低进食障碍和肥胖症的发病率。