Clinical Research in Eating Disorders and Obesity

描述（由申请人提供）：饮食失调和肥胖的临床和公共卫生意义是有据可证的，然而这些问题已知是难以治疗的。本申请是为了申请NIMH面向患者的研究（K24）中期研究者奖，以减轻我的临床、行政和教学职责，以确保50%的保护时间用于指导活动和饮食失调和肥胖领域的面向患者的研究。该应用程序将重点扩展我在饮食失调和肥胖的干预和预防方面的研究，我目前正在进行三项nih资助的研究领域：“BED心理治疗的有效性”（R01 MH64153），“减少饮食失调风险因素的干预”（R01 MH60453）和儿童肥胖：维持方法”（R01 HD36904）。这些资助分别侧重于：三种不同治疗暴食症（BED）的长期有效性；评估一个旨在减少饮食失调的风险因素和发病率的互联网项目；两种以家庭为基础的治疗方法的疗效，旨在改善儿童减肥的长期维持。我在获奖期间和长期的总体目标是：1)继续确定和发展有效的治疗饮食失调和肥胖的方法；2)将基础行为科学的概念和方法应用于饮食失调和肥胖的研究，以改进和完善治疗方法；3)明确BED的诊断状况；4)探讨家庭和社会因素在饮食失调和肥胖的病因、预防和治疗中的作用；5)制定旨在预防饮食失调和肥胖的合并症、复发和残疾的早期干预和预防策略；6)确定共同发生疾病的风险和保护因素，特别注意饮食失调与肥胖之间的联系；7)加强我对未来临床科学家的培训和指导，这是我已经表现出强烈承诺的领域。我计划通过获取先进的研究设计和方法方面的专业知识来发挥我的优势；转化研究;儿童和青少年的饮食行为、发育和精神病理代谢过程以及能量摄入和消耗的精确评估。在这些领域获得更多的知识将使我能够进行创新研究，并为我指导的临床研究人员提供更多的机会。考虑到与饮食失调和肥胖相关的高发病率和死亡率，需要不断改进治疗方法，并注重早期干预和预防，以提高治疗成功率，降低饮食失调和肥胖的发病率。

DESCRIPTION (provided by applicant): The clinical and public health significance of eating disorders and obesity are well-documented, yet these problems are known to be resistant to treatment. This application is a request for an NIMH mid-career Investigator Award in Patient Oriented Research (K24) in order to relieve me from clinical, administrative, and teaching duties, to ensure 50% protected time for mentoring activities and patient-oriented research in the fields of eating disorders and obesity. This application will focus on an expansion of my research in intervention and prevention of eating disorders and obesity, areas in which I currently have three ongoing NIH-funded studies: "Effectiveness of Psychological treatments for BED" (R01 MH64153), "Interventions to Reduce Eating Disorder Risk Factors" (R01 MH60453), and Childhood Obesity: A Maintenance Approach" (R01 HD36904). These grants focus on, respectively: the long-term effectiveness of three distinct treatments for binge eating disorder (BED); the evaluation of an Internet program designed to reduce risk factors for and incidence of eating disorders; and the efficacy of two family-based treatments intended to improve long-term maintenance of weight loss in children. My overarching goals during the award period and in the long- term are: 1) to continue identifying and developing efficacious treatments for eating disorders and obesity; 2) to apply concepts and methods from basic behavioral science to the study of eating disorders and obesity in order to improve and refine treatments; 3) to clarify the diagnostic status of BED; 4) to investigate the role of familial and social factors in the etiology, prevention, and treatment of eating disorders and obesity; 5) to develop early intervention and prevention strategies aimed at preventing comorbidity, relapse, and disability in eating disorders and obesity; 6) to identify risk and protective factors for co-occurring illnesses, with particular attention to the links between eating disorders and obesity; and 7) to increase my training and mentoring of future clinical scientists, an area where I have already demonstrated strong commitment. I plan to build on my strengths by acquiring expertise in advanced research designs and methods; translational research; eating behavior, development, and psychopathology in children and adolescents; and metabolic processes and precise assessments of energy intake and expenditure. Becoming more knowledgeable in these areas will allow me to perform innovative research and provide enhanced opportunities for clinical researchers under my tutelage. Given the high morbidity and mortality associated with eating disorders and obesity, a continued refinement of treatment approaches and focus on early intervention and prevention is required to augment the rates of successful treatment responders and decrease the incidence of eating disorders and obesity.