MRS Studies of Brain Mitochondrial Function in Metabolic Syndrome
MRS Studies of Brain Mitochondrial Function in Metabolic Syndrome
批准号:
6844967
负责人:
Douglas Lyle Rothman
金额:
$8.92万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2004
资助国家:
美国
项目状态:
已结题
起止时间:
2004-07-01 至 2009-06-30
中文摘要
这个项目的中心假设是线粒体功能的改变是关键
英文摘要
The central hypothesis of this program project is that altered mitochondrial function is a key
determinant of metabolic syndrome. However while metabolic syndrome has been extensively
characterized in muscle, liver, kidney and pancreas, little is known about how it impacts brain
function. The potential importance of understanding the impact of metabolic syndrome on brain
function is highlighted by two converging lines of evidence. Firstly, recent studies have strongly
implicated impaired brain mitochondrial function in a host of neurodegenerative diseases, including Alzheimer's and temporal lobe epilepsy. Secondly, epidemiological studies have found a several fold enhancement in the total incidence of neurodegenerative diseases in patients with type 2 Diabetes Metlitus. Reduced brain mitochondria in people with severe insulin resistance may be a factor in this increased susceptibility. In project 3 we will take advantage of our recent
developments of MRS methods for non-invasively imaging brain mitochondrial metabolic function to assess whether it is altered in three groups of subjects with metabolic syndrome. These groups are 1) insulin resistant offspring of parents with Type II diabetes, 2) elderly subjects and 3) patients with an identified mutation in a gene coding for mitochondrial tRNA. Recent MRS studies by the Shulman laboratory have shown that all three groups have altered muscle mitochondrial metabolism. Our general hypothesis in this project is that there are similar alterations in brain mitochondrial metabolism in the brain of these subjects as in the muscle and liver. This project will )rovide the first comprehensive study of metabolic syndrome to brain, and may provide new insight nto why subjects with metabolic syndrome are at increased risk of neurodegenerative disease.
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批准号:7984654
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财政年份:2010
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Core Center for Quantitative Neuroscience with magnetic Resonance (QNMR)
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Acquisition of a 7T human MR system for the development of ultra high resolution
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批准号:7127961
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项目类别:
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资助金额:$200.0万
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财政年份:2006
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负责人:Douglas Lyle Rothman
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依托单位:
7T HUMAN MR SYSTEM, ULTRA HIGH RESOLUTION: NEUROSCIENCE
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批准号:7335350
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资助金额:$200.0万
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财政年份:2006
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依托单位:
CORE--MRS/MRI Core
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批准号:6844970
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MRS Studies of Brain Metabolic Adaptations in Diabetes
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依托单位:
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批准号:6862021
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资助金额:$50.93万
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财政年份:2004
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依托单位:
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批准号:6953726
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资助金额:$52.44万
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财政年份:2004
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Measurement of cortical glutamate, glutamine & GABA levels
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资助金额:$1.53万
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财政年份:2003
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依托单位:
11.74T/210 Millimeter NMR Magnet System/In VivO MRS/MRI
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批准号:6440930
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资助金额:$50.0万
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财政年份:2002
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依托单位:
SPECTROSCOPY CONSOLE AND GRADIENTS FOR 7T NMR SYSTEM
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项目类别:
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财政年份:1998
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负责人:Douglas Lyle Rothman
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依托单位:
MRS STUDIES OF NEUROTRANSMITTER CYCLING IN HUMAN BRAIN
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批准号:6363921
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项目类别:
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依托单位:
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财政年份:1998
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