Console and gradient upgrade for a 9.4 T 16 cm in vivo MR system

9.4 T 16 cm 体内 MR 系统的控制台和梯度升级

• 批准号: 8826292
• 负责人: Douglas Lyle Rothman
• 金额: $ 60万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-03-01 至 2017-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8826292
• 关键词: 10 year old; 7 year old; Advanced Development; Animal Model; Animals; Award; Cancer Grant Supplements (P30); Development; Disease; Exploratory/Developmental Grant for Diagnostic Cancer Imaging; Faculty; Functional Magnetic Resonance Imaging; Funding; Housing; Institution; K-Series Research Career Programs; Magnetic Resonance Imaging; Marketing; Metabolic; Methodology; Methods; Mus; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Neurological Disorders and Stroke; Performance; Phenotype; Productivity; Research; Research Support; Resources; Site; System; Time; United States National Institutes of Health; Withdrawal; base; experience; in vivo; metabolic abnormality assessment; novel; programs; ranpirnase; ultra high resolution

 DESCRIPTION (provided by applicant): The Yale MRRC is a pioneer and leading site for using 1H, and 13C MRS and ultra-high resolution fMRI to study metabolism and function in small animal models. The 9.4T 21 cm animal system at the MRRC is the workhorse for these studies since installation in 2004. It presently supports the research of 22 NIH funded faculty at Yale and other institutions including 9 major users. The NIH support for the user group is 25 awards including 2 Center grants (P30, U24) a P01, 18 R01 awards, a DP1 award, an R21, and 2 K awards. It is a major resource for Yale's NINDS P30 MR Core Center and NIDDK Mouse Metabolic Phenotyping Center. However the continued development of novel MR methodology and groundbreaking applications to disease, that have been the hallmark of the research programs on the system, is severely compromised by limitations in its 7 year old Agilent console and 10 year old gradient hardware. Furthermore with the withdrawal of Agilent from the MRI market there is minimal support available for the console which is already leading to substantial system down time. In order to sustain and enhance the productivity of the User group we propose to replace the present console and gradient system with a state of the art Bruker console and gradient coil. Our selection is based upon the high performance capabilities of the Bruker console and gradient coil and our extensive in house experience in operating and maintaining Bruker systems The new console will insure for years to come the reliable performance of a wide range of state of the art MR methods by the User group, and the continued development of advanced MR methods.

 描述（由申请人提供）：耶鲁MRRC是使用1H和13C MRS和超高分辨率fMRI研究小动物模型代谢和功能的先驱和领先研究中心。自2004年安装以来，MRRC的9.4T 21 cm动物系统是这些研究的主力。它目前支持耶鲁大学和其他机构的22名NIH资助教师的研究，包括9个主要用户。NIH对用户组的支持是25个奖项，包括2个中心赠款（P30，U24），P01，18个R01奖项，DP1奖项，R21和2个K奖项。它是耶鲁大学NINDS P30 MR核心中心和NIDDK小鼠代谢表型中心的主要资源。然而，新的MR方法的持续开发和疾病的突破性应用，一直是该系统研究项目的标志，由于其7年前的Agilent控制台和10年前的梯度硬件的局限性而受到严重影响。此外，随着Agilent从MRI市场的退出，控制台的可用支持最少，这已经导致大量系统停机。为了维持和提高用户组的生产力，我们建议用最先进的Bruker控制台和梯度线圈替换当前的控制台和梯度系统。我们的选择是基于布鲁克控制台和梯度线圈的高性能能力以及我们在操作和维护布鲁克系统方面的丰富内部经验。新控制台将确保用户组在未来几年内可靠地执行各种最先进的MR方法，并继续开发先进的MR方法。