Console for 4T Human MR System

4T 人体 MR 系统控制台

• 批准号: 8246539
• 负责人: Douglas Lyle Rothman
• 金额: $ 59.92万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-07 至 2014-11-06
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8246539
• 关键词: 8 year old; Advanced Development; Brain; Development; Disease; Electronics; Faculty; Funding; Grant; Home environment; Housing; Human; Magnetic Resonance Spectroscopy; Metabolic; Methodology; Methods; Monoclonal Antibody R24; Performance; Productivity; RF coil; Research; Research Support; Small Business Technology Transfer Research; Support System; System; United States National Institutes of Health; base; experience; in vivo; metabolic abnormality assessment; novel; programs; ranpirnase; research study

DESCRIPTION (provided by applicant): The Yale MRRC is a pioneer and leader in the in the study of metabolism by in vivo Magnetic Resonance Spectroscopy (MRS) by 1H and 13C MRS. The 4.0T 94 cm Bruker system has been the traditional workhorse for human metabolic studies and is the only system at the MRRC capable of 13C MRS studies of body and brain. At present the system supports the research of 15 faculty including 9 major users with R01 funding. The NIH support for the user group is 17 grants: 10 R01s, 4 Center grants (R24, P30, and two P50s), an R21, a K02, and an STTR. Most of the PIs using the system have over 10 years of experience using MRS in their research. However the continued development of novel experimental methodology and groundbreaking applications to disease, that have been the hallmark of the research program on system, are severely compromised by the limited capabilities and decreasing reliability of its 8 year old console and electronics. In order to sustain the productivity of the User group we propose to replace the failing Bruker Avance console with a state of the art Agilent console with multiple receiver capability. Our selection is based upon our extensive in house experience in operating and maintaining similar Agilent consoles and integrating them with our home built RF coils and gradient/shim hardware and the extensive MRS capabilities of the system. The new console will allow for years to come the reliable performance of a wide range of sophisticated metabolic experiments by the User group, and insure the continued development of advanced 13C and 1H MRS methods. PUBLIC HEALTH RELEVANCE: Magnetic Resonance Spectroscopy (MRS) is a unique technology that allows chemistry to be imaged throughout the human body. The requested new console for an existing MRS/MRI 4.0T scanner will greatly enhance the research of a highly productive group of NIH funded scientists studying aging, diabetes, neurological and psychiatric disease. Their work has direct relevance for finding new targets for disease treatment and using MRS to evaluate therapies.

描述（由申请人提供）：耶鲁MRRC是通过1H和13 C MRS进行体内磁共振波谱（MRS）代谢研究的先驱和领导者。4.0T 94 cm Bruker系统一直是人体代谢研究的传统主力，是MRRC唯一能够进行身体和大脑13 C MRS研究的系统。目前，该系统支持15个学院的研究，包括9个主要用户与R 01基金。NIH对用户组的支持是17项赠款：10项R 01，4项中心赠款（R24，P30和2项P50），1项R21，1项K 02和1项STTR。大多数使用该系统的PI在其研究中使用MRS的经验超过10年。然而，新的实验方法和突破性的疾病应用的持续发展，一直是系统研究计划的标志，严重损害了其8岁的控制台和电子设备的有限能力和可靠性下降。为了维持用户组的生产力，我们建议用具有多接收器功能的最先进的Agilent控制台替换故障的Bruker Avance控制台。我们的选择是基于我们在操作和维护类似Agilent控制台以及将其与我们自制的RF线圈和梯度/匀场硬件集成以及系统的广泛MRS功能方面的丰富内部经验。新的控制台将允许用户组在未来几年内可靠地进行各种复杂的代谢实验，并确保先进的13 C和1H MRS方法的持续发展。 公共卫生相关性：磁共振波谱（MRS）是一种独特的技术，可以对整个人体进行化学成像。现有MRS/MRI 4.0T扫描仪所需的新控制台将大大增强NIH资助的研究衰老、糖尿病、神经和精神疾病的科学家的高生产力研究。他们的工作与寻找疾病治疗的新靶点和使用MRS评估治疗方法直接相关。