Manganese, Iron, Cadmium & Lead Transport from the Environment to Critical Organs

项目#3探索铁、锰、镉和铅从儿童所经历的环境中运输到血液和关键器官，如大脑、心脏、肝脏和肾脏。我们试图通过(1)利用怀孕期间和怀孕后的暴露，(2)利用来自Tar Creek的金属离子和复杂环境样本，以及(3)比较不同的途径，更好地了解儿童及其母亲在Tar Creek等环境中的金属暴露情况

Project #3 explores the transport of iron, manganese, cadmium and lead from environments experienced by children to the blood and critical organs like the brain, heart, liver, and kidney. We seek to better understand metal exposures of children and their mothers in settings like Tar Creek by (1) utilizing exposures during and after pregnancy, (2) using metal ions as well as complex environmental samples from Tar Creek, and (3) comparing different routes of entry from the environment into the body. Project 3 will also explore the role of toxic metals and iron status as they interact to influence metal absorption. In animal models, we will simultaneously study both the molecular mechanisms of metal transport as well as the corresponding pharmacokinetics of metals from the nose, lung and gut to the blood, central nervous system, and other organs. These data will be correlated with outcomes in both animal (Project 4) and human studies (Project 1). When data from Project 3 are combined with exposure assessment in Project 2, we will be able to better identify which routes of exposure result in the most significant body burdens of toxic metals. From this knowledge, we should be able to craft optimal strategies in Tar Creek to reduce the dose of toxic metals to mothers and children and thus better respond to the environmental concerns of the citizens in Tar Creek, Oklahoma.