African swine fever virus multigene family interferon inhibitory proteins: Functions and application to vaccine development

非洲猪瘟是最具破坏性的猪病之一，目前还没有商业化的疫苗来预防它。本项目旨在推进非洲猪瘟病毒基因缺失减毒活疫苗的开发。我们将研究病毒多基因家族蛋白如何抑制I型干扰素诱导，以及它们是否作用于其他宿主途径。我们的工作将有助于阐明这些蛋白质如何破坏宿主的先天免疫反应，以及它们是否适合从病毒基因组中删除，以开发有效和安全的疫苗。

African swine fever is one of the most devastating swine diseases and there are currently no commercially available vaccines to prevent it. This project aims to advance the development of a gene-deletedlive attenuated vaccine against African Swine Fever Virus. We'll investigate how the viral Multigene Family proteins function to inhibit type I interferon induction and whether they act upon other host pathways. Our work will help elucidate how these proteins act to subvert the host innate immune response, and their suitability for deletion from the viral genome for the development of effective and safe vaccines.