Catalytic and biocatalytic C-X bond formation

催化和生物催化 C-X 键形成

• 批准号: 2449034
• 金额: --
• 依托单位: University of St Andrews
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2449034
• 关键词: Catalytic; biocatalytic; bond; formation

This project will focus on the development of new catalytic approaches for C-X bond activation and C-X bond formation using bioinspired hydrogen bond donor catalysts. The project will initially focus on the activation of C-F bonds and installation of C-B bonds but will likely expand to other systems. The project will involve synthesis of model systems to understand the desired bond activation/formation. This will lead to a methodology encompassing optimisation stages, catalyst modelling, and assessment of scope. Throughout, physical-organic chemistry techniques will be used to understand mechanism and inform on the process under development.

该项目将专注于开发使用生物启发氢键供体催化剂的C-X键活化和C-X键形成的新催化方法。该项目最初将专注于C-F键的激活和C-B键的安装，但可能会扩展到其他系统。该项目将涉及模型系统的合成，以了解所需的键激活/形成。这将产生一种包括优化阶段、催化剂建模和范围评估的方法。在整个过程中，物理-有机化学技术将用于了解机制并告知正在开发的过程。