Exploring the haemagglutinin-neuraminidase of human parainfluenza virus

人副流感病毒血凝素神经氨酸酶的探索

• 批准号: nhmrc : 1047824
• 负责人: Dr Ibrahim El-Deeb
• 金额: $ 48.76万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/exploring-haemagglutinin-neuraminidase-parainfluenza-virus/111973
• 关键词: Exploring; haemagglutinin; neuraminidase; human; parainfluenza

Respiratory diseases, for example croup, in children are caused in the main by human parainfluenza viruses (hPIVs). No vaccines or specific antiviral therapy against hPIV infections exist. This project targets an essential protein in the virus’ lifecycle. This project will produce compounds that block the protein’s function and may provide drug candidates for development. Furthermore the role of human host cell-associated carbohydrates in parainfluenza infection will be better understood.

例如，儿童呼吸道疾病主要是由人类副流感病毒（hpiv）引起的。目前还没有针对hPIV感染的疫苗或特异性抗病毒治疗。该项目以病毒生命周期中的一种重要蛋白质为目标。该项目将产生阻断蛋白质功能的化合物，并可能为开发提供候选药物。此外，人类宿主细胞相关碳水化合物在副流感感染中的作用将得到更好的理解。