Development of Advanced Micro-Nano topological Platforms for Point-of-Care Diagnostics

开发用于即时诊断的先进微纳米拓扑平台

• 批准号: 2449876
• 金额: --
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2449876
• 关键词: Development; Advanced; Micro; Nano; topological

A review article has been submitted as one of the co-authors to the Nano Today journal titled 'Emerging Lithographic Techniques for Nanostructure Fabrication'.The review article covers the emerging techniques in micro-nano-fabrication techniques addressing their strengths and limitations. It focused mainly on the latest advances in the main emerging patterning methods.The emerging methods enable structural and chemical micro-nanofabrication while comparing these innovations to established lithographic techniques. The current project is towards a journal article as the primary author. This will include results obtained from simulation and experimental work on surface-enhanced Raman scattering (SERS) substrate to enable accurate detection of certain biomarkers present in patients suspected of having a traumatic brain injury. This is at the results-gathering stage both from experiments and simulations, whereby the results obtained will be analysed and discussed with potential co-authors.Another collaboration is in its initial (planning) stage, which will include some colleagues and a separate research group focusing on graphene biosensors. Graphene-coated substrates offer relatively cheaper alternatives to other metallic-coated substrates while producing a similar level of Raman signal enhancements for the detection of analytes which indicates the onset of certain diseases. They are interested in the current research work on SERS substrates involving surfaced-patterned substrates whereby the collaboration would involve coating produced structured substrates with graphene monolayer. Other aspects of the project would involve other research colleagues' work involving biosensors, to publish an article (and possibly patents) at the end of the project.

作为合著者之一的一篇评论文章已提交给《今日纳米》杂志，题为《用于纳米结构制造的新兴光刻技术》。评论文章涵盖了微纳制造技术中的新兴技术，阐述了它们的优点和局限性。它主要集中在主要新兴图案化方法的最新进展。这些新兴方法使结构和化学微纳米制造成为可能，同时将这些创新与现有的光刻技术进行比较。目前的项目是将一篇期刊文章作为第一作者。这将包括在表面增强拉曼散射(SERS)底物上进行模拟和实验工作获得的结果，以准确检测疑似患有创伤性脑损伤的患者中存在的某些生物标记物。这是从实验和模拟中收集结果的阶段，获得的结果将被分析并与潜在的合著者讨论。另一项合作处于初始(规划)阶段，其中将包括一些同事和一个专注于石墨烯生物传感器的单独研究小组。石墨烯涂层衬底提供了比其他金属涂层衬底相对便宜的替代品，同时产生了类似水平的拉曼信号增强，用于检测分析物，这表明某些疾病的发生。他们对目前涉及表面图案基板的SERS基板的研究工作感兴趣，其中的合作将涉及用石墨烯单分子层来涂层产生的结构基板。该项目的其他方面将涉及其他研究同事涉及生物传感器的工作，在项目结束时发表一篇文章(可能还有专利)。