The Haplotype Map of the Laboratory Mouse Genome

实验室小鼠基因组的单倍型图谱

• 批准号: 6952231
• 负责人: Mark Joseph Daly
• 金额: $ 47.68万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6952231
• 关键词: animal genetic material tag; biotechnology; gene expression; genetic mapping; genome; genotype; laboratory mouse; linkage mapping; phenotype; quantitative trait loci

DESCRIPTION: (provided by applicant) We propose to create a genome-wide haplotype map in 47 frequently used inbred lab strains of mice in order to enable efficient positional cloning and genotype-phenotype correlation studies. Recent data has established that the genomes of commonly used inbred lab mice, the primary mammalian model system, are simple mosaics of long segments from a very small number of distinct Mus musculus sub-species. By providing a complete description of ancestral segments of variation in each modern strain, the map will allow the use of phenotype data from many strains and QTL mapping information from all crosses simultaneously in the fine mapping of genes responsible for medically relevant phenotypic differences.

产品说明：（申请人提供）我们建议在47种常用的近交实验室小鼠品系中创建全基因组单倍型图谱，以便进行高效的位置克隆和基因型-表型相关性研究。 最近的数据已经确定，常用的近交系实验室小鼠的基因组，主要的哺乳动物模型系统，是简单的马赛克的长片段从一个非常小的数量不同的小家鼠亚种。 通过提供每个现代菌株中的祖先变异片段的完整描述，该图谱将允许在负责医学相关表型差异的基因的精细作图中同时使用来自许多菌株的表型数据和来自所有杂交的QTL作图信息。