Reproductive Outcomes in Salon Employees (ROSE)

沙龙员工的生殖结果 (ROSE)

• 批准号: 7008374
• 负责人: Jodi A. Flaws
• 金额: $ 21.8万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7008374
• 关键词: case history; clinical research; consumer product; disease /disorder proneness /risk; environmental exposure; female; female reproductive system disorder; human middle age (35-64); human subject; lifestyle; occupational hazard; occupational health /safety; ovary disorder; questionnaires; reproduction; ultrasound; young adult human (21-34)

DESCRIPTION (provided by applicant): Cosmetologists are primarily defined as hairdressers who work in retail or home-based salons. They constitute a major occupational group of female workers who sustain chemical exposures during their reproductive lifespan. In fact, it is estimated that there are between 500,000 and 750,000 cosmetologists in the United States alone, and that 80-85% of these workers are women. In general, cosmetologists are exposed to a variety of chemicals on a daily basis, including bleaches, hair dyes, non-lye relaxers, alcohols, methacrylate, ethylene glycol, and pthalates. Although several of these chemicals are known to cause reproductive dysfunction in animal models, few studies have examined whether they are associated with reproductive dysfunction in humans. In addition, no studies have examined the underlying mechanisms by which chemical exposures in cosmetology businesses are associated with reproductive dysfunction in women. Thus, the proposed work will test the hypothesis that exposure to chemicals used in cosmetology businesses is associated with reproductive abnormalities in women through mechanisms involving destruction of ovarian follicles. To test this hypothesis, this work will: 1) determine whether cosmetologists have an increased risk of reproductive abnormalities compared to women who are not cosmetologists and 2) investigate whether cosmetologists have reduced ovarian volume and follicle numbers compared to women who are not cosmetologists. To complete the proposed work, a cross-sectional study will be conducted in 1500 female cosmetologists and 500 women not exposed to chemicals used in hair/nail salons (i.e., retail sales clerks). Each participant will complete a self-administered questionnaire that assesses demographics, reproductive functioning, medical and lifestyle history, and chemical exposures. A subset of women from the cross-sectional study (30 infertile cosmetologists, 30 fertile cosmetologists, and 30 retail sales clerks) will have a transvaginal ultrasound to measure ovarian volume and follicle numbers. Data from the questionnaires will be used to compare reproductive function in cosmetologists and retail sales clerks. Data from the transvaginal ultrasounds will be used to compare ovarian volume and follicle numbers in cosemetolgoists and sales clerks. The results of this study will help determine whether exposures in cosmetology businesses are associated with reproductive dysfunction in women.

描述（由申请人提供）：美容师主要定义为从事零售或家庭沙龙工作的美发师。他们构成了一群主要的职业女性，他们在生殖寿命期间维持化学曝光。实际上，据估计，仅美国就有500,000至750,000名美容学家，其中80-85％的工人是女性。通常，美容师每天都会暴露于各种化学物质，包括漂白剂，染发剂，非乳液松弛剂，醇，甲基丙烯酸酯，乙二醇和pthalates。尽管已知这些化学物质中的几种在动物模型中引起生殖功能障碍，但很少有研究检查它们是否与人类的生殖功能障碍有关。此外，尚无研究检查美容业务中化学暴露与女性生殖功能障碍相关的基本机制。因此，拟议的工作将检验以下假设：在美容业务中使用的化学物质的暴露与妇女的生殖异常有关，涉及破坏卵巢卵泡的机制。为了检验这一假设，这项工作将：1）确定与不是美容学家的女性相比，美容师是否有生殖异常的风险增加； 2）研究美容师是否与非美容学家相比，化妆品学家是否减少了卵巢量和卵泡数量。为了完成拟议的工作，将在1500000000名女性美容学家和500名未暴露于头发/指甲沙龙中使用的化学物质的女性（即零售销售员）中进行横断面研究。每个参与者将完成一份自我管理的问卷，该问卷评估人口统计学，生殖功能，医学和生活方式史以及化学暴露。横断面研究的一部分女性（30名不育美容师，30名肥沃的美容学家和30个零售店文员）将具有经阴道超声检查以测量卵巢量和卵泡数量。问卷的数据将用于比较美容师和零售业务员中的生殖功能。经阴道超声波的数据将用于比较cosemetolgoist和销售文员中的卵巢量和卵泡数量。这项研究的结果将有助于确定美容业务中的暴露是否与女性生殖功能障碍有关。