Phthalate exposure and hot flashes in midlife women
中年女性的邻苯二甲酸盐暴露和潮热
基本信息
- 批准号:9883796
- 负责人:
- 金额:$ 36.88万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-05-01 至 2023-04-30
- 项目状态:已结题
- 来源:
- 关键词:AffectAndrogensAndrostenedioneAntralAnxietyBlood specimenCaringChemically Induced ToxicityChillsDataDevelopmentEstradiolEstrogensEstroneFaceFamilyFatigueFlushingGoalsGonadal Steroid HormonesHealth ExpendituresHormonesHot flushesLeadLifeMeasurementMediatingMedicalMenopauseModelingOutcomeOvarianOvarian FolliclePalpitationsPerimenopausePremature MenopausePrevention strategyProductionProductivityPublic HealthQuality of lifeRecording of previous eventsReportingRiskRisk FactorsRodentSamplingSkinSleep disturbancesStatistical Data InterpretationSweatingSymptomsTestingTestosteroneTransvaginal UltrasoundUnited StatesUrineWagesWomanWomen&aposs HealthWorkagedarmcigarette smokingconsumer productdehydroepiandrosteroneenvironmental chemicalexperienceinhibin Bmiddle agemullerian-inhibiting hormoneovarian failureovarian reservepersonal care productsphthalatesprematureprospectivereproductiveurinary
项目摘要
Hot flashes pose a significant public health problem because they are the most common perimenopausal
symptom reported by women in the United States and the primary reason that women seek medical care
during the menopausal transition. Despite the importance of hot flashes in a woman's life, little is known
about the risk factors for this symptom. Our preliminary data from 195 women (aged 45-54 years) suggest
that phthalate exposures are associated with an increased risk of hot flashes. Specifically, higher
concentrations of phthalates commonly found in personal care products (PCPs) were associated with an
increased risk of ever having hot flashes, having hot flashes in the past 30 days, and frequent hot flashes.
Further, our preliminary data suggest that increased levels of phthalate metabolites are associated with
reduced antral follicle counts, a known risk factor for hot flashes in women. Thus, the overall goal of this
application is to extend our preliminary analysis by testing the hypothesis that urinary phthalate metabolite
concentrations are associated with hot flashes and explore their associations with potential mechanisms
of hot flashes that involve low estrogen levels and ovarian failure. To test this hypothesis, we propose to
complete the following specific aims: 1) prospectively determine whether urinary levels of phthalate
metabolites are associated with subsequent hot flashes, 2) determine whether urinary levels of phthalate
metabolites are associated with low estrogen and androgen levels, 3) determine whether urinary levels of
phthalate metabolites are associated with ovarian follicle loss, and 4) explore whether any observed
associations between urinary phthalate metabolites and hot flashes are mediated by ovarian follicle loss
and/or low levels of sex steroid hormones. To complete these aims, we will use urine and blood samples,
transvaginal ultrasound data, and hot flashes histories that have been obtained from 782 women (aged
45-54 years) who participated in the Midlife Women's Health Study. The urine samples will be subjected
to measurements of phthalate metabolites and the blood samples will be subjected to measurements of
sex steroid hormone levels as well as anti-Müllerian and inhibin B levels. Transvaginal ultrasound data
will be used to determine antral follicle counts and ovarian volume. Statistical analyses then will be
conducted to assess correlations between urinary phthalate levels, hormone levels, antral follicle numbers,
and ovarian volume. Further, statistical analyses will be conducted to examine whether low sex steroid
hormone levels, reduced antral follicle counts, or small ovarian reserve mediate the association between
phthalate metabolites and hot flashes. The results of this study will provide a better understanding of the
risk factors for hot flashes and the mechanisms by which environmental chemicals are associated with
adverse reproductive outcomes in women. This may lead to the development of preventive strategies and
new treatments for hot flashes in women.
潮热是最常见的围绝经期症状,是一个重大的公共卫生问题
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Midlife Urinary Phthalate Metabolite Concentrations and Prior Uterine Fibroid Diagnosis.
- DOI:10.3390/ijerph19052741
- 发表时间:2022-02-26
- 期刊:
- 影响因子:0
- 作者:Pacyga DC;Ryva BA;Nowak RA;Bulun SE;Yin P;Li Z;Flaws JA;Strakovsky RS
- 通讯作者:Strakovsky RS
Preliminary findings reveal that phthalate exposure is associated with both subjective and objective measures of sleep in a small population of midlife women.
- DOI:10.1016/j.maturitas.2021.11.004
- 发表时间:2022-03
- 期刊:
- 影响因子:4.9
- 作者:Hatcher KM;Smith RL;Li Z;Flaws JA;Davies CR;Mahoney MM
- 通讯作者:Mahoney MM
Phthalate exposures and one-year change in body mass index across the menopausal transition.
- DOI:10.1016/j.envres.2020.110598
- 发表时间:2021-03
- 期刊:
- 影响因子:8.3
- 作者:Haggerty DK;Flaws JA;Li Z;Strakovsky RS
- 通讯作者:Strakovsky RS
Association between polycystic ovary syndrome and hot flash presentation during the midlife period.
多囊卵巢综合征与中年期间潮热表现之间的关联。
- DOI:10.1097/gme.0000000000001055
- 发表时间:2018
- 期刊:
- 影响因子:0
- 作者:Yin,Ophelia;Zacur,HowardA;Flaws,JodiA;Christianson,MindyS
- 通讯作者:Christianson,MindyS
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Jodi A. Flaws其他文献
Predictors of menopausal hot flashes.
更年期潮热的预测因子。
- DOI:
- 发表时间:
1998 - 期刊:
- 影响因子:0
- 作者:
Catherine A. Staropoli;Jodi A. Flaws;T. Bush;Anne W. Moulton - 通讯作者:
Anne W. Moulton
High specificity and negative predictive value of exercise testing for long-term mortality in asymptomatic men
- DOI:
10.1016/s0735-1097(02)80603-9 - 发表时间:
2002-03-06 - 期刊:
- 影响因子:
- 作者:
Samia Mora;Yadong Cui;Maura K. Whiteman;Jodi A. Flaws;Roger S. Blumenthal - 通讯作者:
Roger S. Blumenthal
Effects of phthalate exposure on human ovarian extracellular matrix composition: insights from a 3D spheroid model
邻苯二甲酸酯暴露对人卵巢细胞外基质组成的影响:来自三维球体模型的见解
- DOI:
10.1016/j.envres.2025.121797 - 发表时间:
2025-08-15 - 期刊:
- 影响因子:7.700
- 作者:
Saba Nikanfar;Ellen C.R. Leonel;Pauliina Damdimopoulou;Jodi A. Flaws;Christiani A. Amorim - 通讯作者:
Christiani A. Amorim
Year-to-year variation in phthalate metabolites in the Midlife Women’s Health Study
中年女性健康研究中邻苯二甲酸盐代谢物的逐年变化
- DOI:
10.1038/s41370-023-00614-1 - 发表时间:
2023-12-04 - 期刊:
- 影响因子:4.700
- 作者:
Genoa R. Warner;Zhong Li;Jodi A. Flaws;Rebecca Smith - 通讯作者:
Rebecca Smith
Prenatal exposure to a mixture of different phthalates increases the risk of mammary carcinogenesis in F1 female offspring
- DOI:
10.1016/j.fct.2021.112519 - 发表时间:
2021-10-01 - 期刊:
- 影响因子:
- 作者:
Thiago de Freitas;Joyce R. Zapaterini;Cristiane M. Moreira;Ariana M. de Aquino;Luiz G. Alonso-Costa;Lucas T. Bidinotto;Laura Kass;Jodi A. Flaws;Wellerson R. Scarano;Luis F. Barbisan - 通讯作者:
Luis F. Barbisan
Jodi A. Flaws的其他文献
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{{ truncateString('Jodi A. Flaws', 18)}}的其他基金
Phthalate Exposure and Female Reproductive Aging
邻苯二甲酸盐暴露与女性生殖衰老
- 批准号:
10576477 - 财政年份:2022
- 资助金额:
$ 36.88万 - 项目类别:
ToxMSDT: An Innovative Toxicology Pathway mentoring program targeting underrepresented STEM students
ToxMSDT:针对代表性不足的 STEM 学生的创新毒理学途径指导计划
- 批准号:
10689039 - 财政年份:2020
- 资助金额:
$ 36.88万 - 项目类别:
ToxMSDT: An Innovative Toxicology Pathway mentoring program targeting underrepresented STEM students
ToxMSDT:针对代表性不足的 STEM 学生的创新毒理学途径指导计划
- 批准号:
10264887 - 财政年份:2020
- 资助金额:
$ 36.88万 - 项目类别:
ToxMSDT: An Innovative Toxicology Pathway mentoring program targeting underrepresented STEM students
ToxMSDT:针对代表性不足的 STEM 学生的创新毒理学途径指导计划
- 批准号:
10472735 - 财政年份:2020
- 资助金额:
$ 36.88万 - 项目类别:
ToxMSDT: An Innovative Toxicology Pathway mentoring program targeting underrepresented STEM students
ToxMSDT:针对代表性不足的 STEM 学生的创新毒理学途径指导计划
- 批准号:
10056176 - 财政年份:2020
- 资助金额:
$ 36.88万 - 项目类别:
Water disinfection by-products and female fertility
水消毒副产物与女性生育能力
- 批准号:
9564588 - 财政年份:2018
- 资助金额:
$ 36.88万 - 项目类别:
Summer Undergraduate Research Experience in Toxicology
毒理学暑期本科生研究经验
- 批准号:
10322451 - 财政年份:2016
- 资助金额:
$ 36.88万 - 项目类别:
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