KATP channels in normal and injured sensory transduction

正常和受损感觉转导中的 KATP 通道

• 批准号: 6925898
• 负责人: CONSTANTINE D SARANTOPOULOS
• 金额: $ 17.1万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6925898
• 关键词: adenosine triphosphate; afferent nerve; cell death; electrophysiology; ischemia; laboratory rat; membrane potentials; nerve injury; pain; potassium channel; sensory neuropathy; spinal ganglion; stress

DESCRIPTION (provided by applicant): The candidate for the KO8 Award earned an MD and PhD degree from the National and Capodistrian University in Athens, Greece, and an MS degree from the Medical College of Wisconsin. He trained in anesthesia with a fellowship in pain management at the latter institution, where he is currently an Assistant Professor in Anesthesiology. He has participated in basic neurological research relevant to pathophysiology and pharmacology of experimental neuropathic pain, and has developed skills in patch clamp electrophysiology. Opportunities and support provided by the K08 award will significantly amplify his future prospects in achieving independence in translational basic neurophysiologic research. Objectives of the development program through this award are to: 1) ensure unimpeded time to broaden scientific knowledge, enhance research skills, and refine critical analytical abilities; 2) provide course work and interactive settings that will expand independence as a physician-scientist; 3) investigate the molecular pharmacology and function of KATP channels in primary afferent neurons under normal conditions and after neurologic injury-that results in neuropathic pain; and 4) develop skills in planning protocols and collecting preliminary data for further, more advanced funded investigation. The development program will enable the candidate to achieve these goals by providing advanced training in electrophysiological, molecular, and genetic techniques and in a rich and productive academic environment, as well as through progressive course-work. He will be guided in his efforts by an interdisciplinary group of investigators with a documented expertise in the specific research fields relevant to his program. Within this context, the candidate will pursue a structured research program designed to expand his technical and scientific abilities and to reveal the role of neuronal KATP channels in modulating neuronal excitability and cell survival at the DRG level. This award would support the transition of the candidate to autonomy as a physician scientist, and provide preliminary data leading to independent funding of research on mechanisms of painful peripheral neuropathy.

描述（由申请人提供）：KO 8奖的候选人获得了希腊雅典国立卡波季斯特里安大学的医学博士和博士学位，以及威斯康星州医学院的理学硕士学位。他接受了麻醉培训，并在后者的机构获得了疼痛管理奖学金，目前他是麻醉学助理教授。他参与了与实验性神经病理性疼痛的病理生理学和药理学相关的基础神经学研究，并发展了膜片钳电生理学技能。K 08奖提供的机会和支持将大大扩大他在基础神经生理学研究转化中实现独立的未来前景。通过这个奖项的发展计划的目标是：1）确保畅通无阻的时间来扩大科学知识，提高研究技能，并完善关键的分析能力; 2）提供课程工作和互动环境，将扩大作为一个医生科学家的独立性; 3）研究正常条件下和神经损伤后初级传入神经元中KATP通道的分子药理学和功能-导致神经性疼痛; 4）发展规划方案和收集初步数据的技能，用于进一步的、更先进的资助研究。该发展计划将使候选人通过提供电生理，分子和遗传技术的高级培训，并在丰富和富有成效的学术环境中，以及通过渐进的课程工作来实现这些目标。他将由一个跨学科的研究人员小组指导他的工作，该小组在与他的计划相关的特定研究领域具有记录在案的专业知识。在此背景下，候选人将追求一个结构化的研究计划，旨在扩大他的技术和科学能力，并揭示神经元KATP通道在DRG水平调节神经元兴奋性和细胞存活的作用。该奖项将支持候选人作为一名医生科学家的自主权的过渡，并提供初步数据，导致对疼痛性周围神经病变机制的研究的独立资助。