Towards the Development of an Efficient One-Carbon Homologation Strategy for Alkenes

第一年：为CDT的所有一年级学生成员开展的一般培训活动。第2-4年：该项目着眼于制定烯烃的一般性、一锅法、一碳碳同系化战略的长期目标。建议的转换由两个单独的反应，可能会在一锅，或一步，交叉易位的底物烯烃与烯丙基肼，然后串联原位消除还原1，3-转座的肼，以产生homologated olefin.We将首先调查的适用性甲苯磺酰基和nosyl肼底物的烯丙基二氮烯重排。其次，将在与简单的末端烯烃4-苯基-丁烯的交叉复分解中探索甲苯磺酰基和对甲苯磺酰基肼底物的相容性。

Year 1: Generic training activities for all first-year student members of the CDT.Year 2-4: The project looks at the long-term goal of developing a general, one-pot, one-carbon carbon homologation strategy for alkenes. The proposed transformation consists of two individual reactions that could potentially work in one-pot, or one-step, cross-metathesis of the substrate olefin with allyl hydrazine, followed by a tandem in situ elimination-reductive 1,3-transposition of the hydrazine to yield the homologated olefin.We will first investigate the suitability of tosyl and nosyl hydrazine substrates for the allylic diazene rearrangement. Secondly, the compatibility of the tosyl and nosyl hydrazine substrates will be explored in cross-metathesis with a simple terminal alkene, 4-phenyl-butene.