Towards the Development of an Efficient One-Carbon Homologation Strategy for Alkenes

开发高效的烯烃一碳同系化策略

• 批准号: 2468368
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2468368
• 关键词: Towards; Development; Efficient; Carbon; Homologation

Year 1: Generic training activities for all first-year student members of the CDT.Year 2-4: The project looks at the long-term goal of developing a general, one-pot, one-carbon carbon homologation strategy for alkenes. The proposed transformation consists of two individual reactions that could potentially work in one-pot, or one-step, cross-metathesis of the substrate olefin with allyl hydrazine, followed by a tandem in situ elimination-reductive 1,3-transposition of the hydrazine to yield the homologated olefin.We will first investigate the suitability of tosyl and nosyl hydrazine substrates for the allylic diazene rearrangement. Secondly, the compatibility of the tosyl and nosyl hydrazine substrates will be explored in cross-metathesis with a simple terminal alkene, 4-phenyl-butene.

第一年：为CDT的所有一年级学生成员开展的一般培训活动。第2-4年：该项目着眼于制定烯烃的一般性、一锅法、一碳碳同系化战略的长期目标。拟议的转化由两个单独的反应组成，这些反应可能会在底物烯烃与烯丙基肼的一锅或一步交叉复分解中进行，然后串联原位消除-还原肼的1，3-转座以产生同系烯烃。我们将首先研究对甲苯磺酰基和对甲苯磺酰基肼底物对烯丙基二氮烯重排的适用性。其次，将在与简单的末端烯烃4-苯基-丁烯的交叉复分解中探索甲苯磺酰基和对甲苯磺酰基肼底物的相容性。