Towards the Development of an Efficient One-Carbon Homologation Strategy for Alkenes

第一年：为CDT所有一年级学生成员提供一般培训活动。第2-4年：该项目的长期目标是为烯烃制定一种通用的、一罐、一碳的碳同源策略。提议的转化包括两个单独的反应，可能在一锅或一步中进行，底物烯烃与烯丙基肼的交叉复分解，然后是肼的串联原位消除-还原1,3转位，以产生同源烯烃。我们将首先研究tosyl和nosyl肼底物对烯丙基重氮重排的适用性。其次，探讨了甲酰肼和甲酰肼底物与简单末端烯烃4-苯基丁烯的交叉复合反应的相容性。

Year 1: Generic training activities for all first-year student members of the CDT.Year 2-4: The project looks at the long-term goal of developing a general, one-pot, one-carbon carbon homologation strategy for alkenes. The proposed transformation consists of two individual reactions that could potentially work in one-pot, or one-step, cross-metathesis of the substrate olefin with allyl hydrazine, followed by a tandem in situ elimination-reductive 1,3-transposition of the hydrazine to yield the homologated olefin.We will first investigate the suitability of tosyl and nosyl hydrazine substrates for the allylic diazene rearrangement. Secondly, the compatibility of the tosyl and nosyl hydrazine substrates will be explored in cross-metathesis with a simple terminal alkene, 4-phenyl-butene.