Towards the Development of an Efficient One-Carbon Homologation Strategy for Alkenes

第1年：CDT所有一年级学生成员的通用培训活动。第2至第4年：该项目着眼于制定一种一般的、一锅一碳的烯烃碳同源战略的长期目标。所提出的转化包括两个单独的反应，这两个反应可能在底物烯烃与烯丙基肼的一锅或一步交叉易位中起作用，然后将肼进行串联的原位消除-还原1，3-转位得到同系化的烯烃。我们将首先研究对甲苯磺酰和诺苯肼底物对烯丙基重氮烯重排的适用性。其次，将通过与简单的末端烯烃4-苯基丁烯的交叉易位反应来探索对甲苯磺酰肼和诺苯肼底物的相容性。

Year 1: Generic training activities for all first-year student members of the CDT.Year 2-4: The project looks at the long-term goal of developing a general, one-pot, one-carbon carbon homologation strategy for alkenes. The proposed transformation consists of two individual reactions that could potentially work in one-pot, or one-step, cross-metathesis of the substrate olefin with allyl hydrazine, followed by a tandem in situ elimination-reductive 1,3-transposition of the hydrazine to yield the homologated olefin.We will first investigate the suitability of tosyl and nosyl hydrazine substrates for the allylic diazene rearrangement. Secondly, the compatibility of the tosyl and nosyl hydrazine substrates will be explored in cross-metathesis with a simple terminal alkene, 4-phenyl-butene.