PEROMYSCUS LABORATORY MODELS FOR BIOMEDICAL RESEARCH

描述(申请人提供)：鹿鼠(Permyscus Manulatus)和同属物种是北美最丰富、物种最多、分布最广的哺乳动物之一。它们分布在从阿拉斯加到中美洲的许多自然栖息地，经常被用作研究适应生理和行为的基本过程的模型，也被用来监测环境毒理学。它们直接影响着美国人类健康的许多方面，因为美国是传染病生物体的储藏库。PGSC成立于1985年，为国家科学和教育界提供了这些动物和相关材料的可靠来源。该库存中心建议继续为生物医学和相关研究提供Permyscus，以推广该物种及其优势，并提高Permyscus作为实验室模式的实用性。一个目标是开发Permyscus生发材料的超低温保存技术，从而能够经济地保存突变体库。未来几年的另一个目标是开发由基于聚合酶链式反应(PCR)的标记组成的Permyscus遗传图谱。即将完成的人类和实验室小鼠基因组计划的一个好处是，这些信息可以随时应用于非传统物种，如Permyscus。在Permyscus中，有许多生物医学和基础研究人员感兴趣的问题，对这些问题来说，基因组方法可能是值得的。

DESCRIPTION (provided by applicant): The deer mouse (Peromyscus maniculatus) and co-generic species are among the most abundant, species, and widely distributed North American mammals. Ranging from Alaska to Central America and occurring in many natural habitats they are frequently used as models to study the fundamental processes underlying adaptive physiology and behavior and are also used to monitor environmental toxicology. They directly affect many aspects of human health in the United States as reservoirs for infectious disease organisms. Established in 1985, the PGSC provides a reliable source of these animals and related materials to the national scientific and educational communities. The Stock Center proposes to continue providing peromyscines for biomedical and related research, to promote the species and its advantages, and to improve the usefulness of Peromyscus as a laboratory model. One aim is the development of cryopreservation technology for Peromyscus germinal material, thereby enabling economical preservation of mutant stocks. Another aim in the next several years is the development of a Peromyscus genetic map composed of polymerase chain reaction (PCR) based markers. A benefit of the nearly completed human and laboratory mouse genome projects is the ready application of that information to non-traditional species such as Peromyscus. In Peromyscus there are numerous questions of interest to biomedical and basic researchers for which genomic approaches would likely be worthwhile.