PEROMYSCUS LABORATORY MODELS FOR BIOMEDICAL RESEARCH

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。关于艾滋病描述（由申请人提供）：鹿鼠（Peromyscus maniculatus）和同属物种是北美最丰富的物种和广泛分布的哺乳动物。从阿拉斯加到中美洲，在许多自然栖息地都有，它们经常被用作研究适应性生理和行为的基本过程的模型，也被用于监测环境毒理学。它们作为传染病微生物的宿主，直接影响美国人类健康的许多方面。PGSC成立于1985年，为国家科学和教育界提供这些动物和相关材料的可靠来源。该股票中心建议继续提供peromyscines生物医学和相关研究，以促进物种及其优势，并提高Peromyscus作为实验室模型的有用性。目的之一是开发用于Peromyscus germinus材料的冷冻保存技术，从而能够经济地保存突变体原种。未来几年的另一个目标是开发由基于聚合酶链反应（PCR）的标记组成的Peromyscus遗传图谱。即将完成的人类和实验室小鼠基因组计划的一个好处是可以将这些信息应用于非传统物种，如Peromyscus。在Peromyscus中，有许多生物医学和基础研究人员感兴趣的问题，基因组方法可能是值得的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Regarding AIDS DESCRIPTION (provided by applicant): The deer mouse (Peromyscus maniculatus) and co-generic species are among the most abundant, species, and widely distributed North American mammals. Ranging from Alaska to Central America and occurring in many natural habitats they are frequently used as models to study the fundamental processes underlying adaptive physiology and behavior and are also used to monitor environmental toxicology. They directly affect many aspects of human health in the United States as reservoirs for infectious disease organisms. Established in 1985, the PGSC provides a reliable source of these animals and related materials to the national scientific and educational communities. The Stock Center proposes to continue providing peromyscines for biomedical and related research, to promote the species and its advantages, and to improve the usefulness of Peromyscus as a laboratory model. One aim is the development of cryopreservation technology for Peromyscus germinal material, thereby enabling economical preservation of mutant stocks. Another aim in the next several years is the development of a Peromyscus genetic map composed of polymerase chain reaction (PCR) based markers. A benefit of the nearly completed human and laboratory mouse genome projects is the ready application of that information to non-traditional species such as Peromyscus. In Peromyscus there are numerous questions of interest to biomedical and basic researchers for which genomic approaches would likely be worthwhile.