PEROMYSCUS LABORATORY MODELS FOR BIOMEDICAL RESEARCH

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。关于艾滋病描述（申请人提供）：鹿鼠（Peromyscus maniculatus）及其共属种是数量最多、种类最多、分布最广的北美哺乳动物之一。从阿拉斯加到中美洲，发生在许多自然栖息地，它们经常被用作研究适应性生理和行为的基本过程的模型，也被用于监测环境毒理学。它们作为传染病有机体的宿主，直接影响着美国人健康的许多方面。PGSC成立于1985年，为国家科学和教育界提供了这些动物和相关材料的可靠来源。斯托克中心建议继续提供高omyscus用于生物医学和相关研究，推广该物种及其优势，并提高高omyscus作为实验室模型的实用性。其中一个目标是发展冷冻保存技术的Peromyscus生发材料，从而使经济保存突变体库存。在未来几年的另一个目标是开发一个由聚合酶链反应（PCR）为基础的标记组成的Peromyscus遗传图谱。即将完成的人类和实验室小鼠基因组计划的一个好处是，这些信息可以随时应用于像Peromyscus这样的非传统物种。在Peromyscus中，有许多生物医学和基础研究人员感兴趣的问题，其中基因组方法可能是值得的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Regarding AIDS DESCRIPTION (provided by applicant): The deer mouse (Peromyscus maniculatus) and co-generic species are among the most abundant, species, and widely distributed North American mammals. Ranging from Alaska to Central America and occurring in many natural habitats they are frequently used as models to study the fundamental processes underlying adaptive physiology and behavior and are also used to monitor environmental toxicology. They directly affect many aspects of human health in the United States as reservoirs for infectious disease organisms. Established in 1985, the PGSC provides a reliable source of these animals and related materials to the national scientific and educational communities. The Stock Center proposes to continue providing peromyscines for biomedical and related research, to promote the species and its advantages, and to improve the usefulness of Peromyscus as a laboratory model. One aim is the development of cryopreservation technology for Peromyscus germinal material, thereby enabling economical preservation of mutant stocks. Another aim in the next several years is the development of a Peromyscus genetic map composed of polymerase chain reaction (PCR) based markers. A benefit of the nearly completed human and laboratory mouse genome projects is the ready application of that information to non-traditional species such as Peromyscus. In Peromyscus there are numerous questions of interest to biomedical and basic researchers for which genomic approaches would likely be worthwhile.