PEROBASE: A BIOLOGICAL DATABASE FOR PEROMYSCUS

PEROBASE：PROMYSCUS 的生物数据库

• 批准号: 7153937
• 负责人: MICHAEL J DEWEY
• 金额: $ 0.36万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7153937
• 关键词: Peromyscus; animal colony; biological models

DESCRIPTION (provided by applicant): The deer mouse (Peromyscus maniculatus) and co-generic species are among the most abundant, species, and widely distributed North American mammals. Ranging from Alaska to Central America and occurring in many natural habitats they are frequently used as models to study the fundamental processes underlying adaptive physiology and behavior and are also used to monitor environmental toxicology. They directly affect many aspects of human health in the United States as reservoirs for infectious disease organisms. Established in 1985, the PGSC provides a reliable source of these animals and related materials to the national scientific and educational communities. The Stock Center proposes to continue providing peromyscines for biomedical and related research, to promote the species and its advantages, and to improve the usefulness of Peromyscus as a laboratory model. One aim is the development of cryopreservation technology for Peromyscus germinal material, thereby enabling economical preservation of mutant stocks. Another aim in the next several years is the development of a Peromyscus genetic map composed of polymerase chain reaction (PCR) based markers. A benefit of the nearly completed human and laboratory mouse genome projects is the ready application of that information to non-traditional species such as Peromyscus. In Peromyscus there are numerous questions of interest to biomedical and basic researchers for which genomic approaches would likely be worthwhile.

描述（由申请人提供）：鹿鼠（Peromyscus maniculatus）及其属种是北美最丰富、最广泛分布的哺乳动物。 它们的范围从阿拉斯加到中美洲，分布在许多自然栖息地，经常被用作模型来研究适应性生理和行为的基本过程，也用于监测环境毒理学。 它们作为传染病微生物的宿主，直接影响美国人类健康的许多方面。 PGSC成立于1985年，为国家科学和教育界提供这些动物和相关材料的可靠来源。 该股票中心建议继续提供peromyscines生物医学和相关研究，以促进物种及其优势，并提高peromyscus作为实验室模型的有用性。 目的之一是开发用于Peromyscus germinus材料的冷冻保存技术，从而能够经济地保存突变体原种。 未来几年的另一个目标是开发由基于聚合酶链反应（PCR）的标记组成的Peromyscus遗传图谱。 即将完成的人类和实验室小鼠基因组计划的一个好处是可以将这些信息应用于非传统物种，如Peromyscus。 在Peromyscus中，有许多生物医学和基础研究人员感兴趣的问题，基因组方法可能是值得的。