CORE GRANT IN VISION RESEARCH

描述（由申请人提供）：横跨文理学院、皮博迪教育学院、工程学院和医学院的范德比尔特视觉研究中心（VVRC）要求为四个模块和一个新模块提供不中断的支持。(1)动物护理模块提供非人类灵长类动物和其他大型动物的专业育种、富集、手术支持和兽医护理，以及转基因小鼠的基因分型和表型分型。这些服务不是由范德比尔特动物保护部门提供的。(2)计算机模块提供硬件安装和维护，软件开发，用于视觉显示和实时数据采集和分析，网页维护和制作期刊、幻灯片和海报的插图。(3)图像处理模块辅助光学成像、功能磁共振成像等成像数据的采集和分析。本模块还将提供共聚焦显微镜的访问和支持。(4)车间模块修理、设计和制造专门的光学、机械和电子仪器。还要求支持新的基因和蛋白质分析模块，该模块将提供经济的基因微阵列和蛋白质质谱服务。要求提供行政支助，以确保刚果民主共和国研究和培训特派团继续顺利和稳定地运作。模块由NEI资助的调查人员指导，拥有有才能和经验丰富的工作人员，并提供否则无法获得或过于昂贵或缓慢的服务。在上一个拨款期间，每个模块被不少于5名研究人员适度或广泛地使用。VVRC的研究人员发表了数百篇论文，为基础和临床视觉科学做出了重要贡献。核心拨款增加了范德比尔特大学校园和其他机构的基础和临床视觉研究人员之间的合作。核心拨款提高了我们为范德比尔特大学招募世界级视觉研究人员的能力，从而使nei资助的范德比尔特大学的研究增加了一倍多。VVRC研究人员的高水平表现取决于新的核心拨款支持，与范德比尔特大学生物医学研究和培训的校园范围内的举措协同作用。

DESCRIPTION (provided by applicant): The Vanderbilt Vision Research Center (VVRC) spanning the College of Arts & Science, Peabody College of Education, School of Engineering and School of Medicine requests uninterrupted support for four modules plus support for one new module. (1) The Animal Care Module provides specialized breeding, enrichment, surgical support and veterinary care of nonhuman primates and other large animals as well as genotyping and phenotyping of transgenic mice. These services not provided by the Vanderbilt Division of Animal Care. (2) The Computer Module provides hardware installation and maintenance, software development for visual displays and real-time data acquisition and analysis, webpage maintenance and production of illustrations for journals, slides and posters. (3) The Image Processing Module aids acquisition and analysis of optical imaging, fMRI and other imaging data. This module will also provide access to and support of confocal microscopy. (4) The Shop Module repairs, designs and fabricates specialized optical, mechanical and electronic instruments. Support is also requested for a new Gene & Protein Analysis Module that will provide economical access to gene microarray and protein mass spectrometry services. Administrative support is requested to ensure continued smooth and stable operation of the VVRC research and training missions. Modules are directed by investigators with NEI funding, have talented and experienced staff and provide services that are otherwise not available or would be prohibitively expensive or slow. During the last grant period, each module was used moderately or extensively by no less than five investigators. VVRC investigators produced several hundred publications that made fundamental contributions to basic and clinical visual science. The Core grant has increased collaborations between basic and clinical vision researchers across the Vanderbilt campus and with other institutions. The Core grant has improved our ability to recruit world-class vision researchers to Vanderbilt resulting in a more-thandoubling of NEI-sponsored research at Vanderbilt. The high level of performance of VVRC investigators, which depends on renewed Core grant support, synergizes with campus-wide initiatives in biomedical research and training at Vanderbilt.