NERVOUS SYSTEM DEVELOPMENT AND INJURY

神经系统发育和损伤

• 批准号: 7108491
• 负责人: DAVID M. HOLTZMAN
• 金额: $ 6.12万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7108491
• 关键词: NERVOUS; SYSTEM; DEVELOPMENT; INJURY

EXCEED THE SPACE PROVIDED. The present application seeks continued funding for two training programs at Washington University, one that has been jointly administered by the Departmentsof Neurology and Neurological Surgery for the past 19 years, and another that has been administered by the Division of Pediatric Neurology for the past eight years. The latter, the Neurological Sciences Academic Development Award, cannot be renewed. We seek to provide a program of extended research training for selected trainees in Neurology, Neurosurgery, or Pediatric Neurology, preparing for academic careers. To take advantageof progress in translational neuroscience research over the last few years, we have increased the emphasis of our training program on patient-oriented research. We thus intend to augment our historical emphasis on bench research by offering our trainees the opportunity to gain a rigorous education in clinical research methodology. We believe that the next advances in clinical neurology and neurosurgery will be brought into practice by investigators who combine clinical expertise with formal education in this methodology/Trainees participating in our training program will be expected to devoteat least two years of near full-time effort beyond residency training to the task. This is likely the minimum period necessary to develop the scientifically-trained neurological or neurosurgical clinicians who will be essential for elucidating the pathogenesis of nervous system diseases, and bringing new therapies to patients. Despite accelerating neuroscience research advances, there is presently a serious shortage of neurological or neurosurgical physician-scientists or clinical researchers capable of performing these essential translational functions. Indeed, the American Neurological Association currently lists over 150 open positions in academic neurology alone. Exploiting current strengths, both within the training units themselves (Neurology, Neurosurgery, and Pediatric Neurology), and within the larger neuroscience community at Washington University, the proposed program will continue to focus on two major themes: Nervous System Injury, and Nervous System Development. These twin themes are active fronts in disease-related neuroscience today, relevant to understanding the pathogenesis of many different neurological diseases. These themes are complementary, as well as partially overlapping. Insights gained into the nature of the developing nervous system are highly likely to be relevant to understanding nervous system responses to injury. PERFORMANCE SITE ========================================Section End===========================================

超出所提供的空间。 本申请寻求继续为华盛顿大学的两个培训项目提供资金，其中一个项目在过去 19 年里一直由神经内科和神经外科部门联合管理，另一个项目在过去 8 年里一直由小儿神经病学部门管理。后者，即神经科学学术发展奖，不能续展。我们寻求为神经病学、神经外科或小儿神经病学的选定学员提供扩展研究培训计划，为学术生涯做好准备。为了利用过去几年转化神经科学研究的进展，我们的培训计划更加重视以患者为导向的研究。因此，我们打算通过为学员提供接受严格的临床研究方法教育的机会来加强我们对实验室研究的历史重视。我们相信，临床神经病学和神经外科的下一步进展将由将临床专业知识与该方法的正规教育相结合的研究人员付诸实践/参加我们培训计划的学员将需要在住院医师培训之外投入至少两年的近乎全职的努力来完成这项任务。这可能是培养经过科学训练的神经病学或神经外科临床医生所需的最短时间，他们对于阐明神经系统疾病的发病机制以及为患者带来新的疗法至关重要。尽管神经科学研究不断取得进展，但目前仍严重缺乏能够执行这些基本转化功能的神经病学或神经外科医师科学家或临床研究人员。事实上，美国神经病学协会目前仅在学术神经病学领域就列出了 150 多个空缺职位。 利用培训单位本身（神经病学、神经外科和小儿神经病学）以及华盛顿大学更大的神经科学界的现有优势，拟议的计划将继续关注两大主题：神经系统损伤和神经系统发展。这些孪生主题是当今疾病相关神经科学的活跃前沿，与理解许多不同神经系统疾病的发病机制相关。这些主题是互补的，也有部分重叠。对发育中神经系统本质的深入了解很可能与理解神经系统对损伤的反应有关。表演网站==========================================章节结束===============================================