PROGRAM OF RESEARCH TRAINING IN REPRODUCTIVE BIOLOGY

超出所提供的空间。这个已建立并不断发展的跨学科项目的目的是培养分子生物学、内分泌学、分子遗传学和生殖综合生理学方面的博士后和博士前研究员。现有博士后17人，博士生在读前51人，均具有内分泌学、生殖生物学、神经生物学、分子生物学等生物学科背景经验。在动物科学、生物化学、分子与综合生理学和兽医生物科学四个学科相关部门（一些教师在细胞和结构生物学交叉任命）中任命了15名教师，为研究培训提供了广泛和深入的机会。目前关于各类生殖激素的项目涵盖了男性和女性生殖生物学的许多方面。研究在分子、细胞、器官和整个动物水平上对小型和大型动物进行。正在进行的研究项目与主要的国家健康相关目标直接相关，例如调节男性和女性的生育能力，阻止激素依赖性乳腺癌和前列腺癌的生长，提供绝经后骨骼脱矿保护，了解子宫内膜异位症和子宫肌瘤的原因并确保治疗，防止分娩时间延长和分娩困难，以及确定环境中破坏生殖系统的物质的特征。博士后学员主要从事独立的原创性研究，一般在3-4年内完成培训。博士预科生在开始独立研究之前，要学习内分泌学和生殖生理学以及相关学科，如生物化学、分子生物学、免疫学和统计学。完成博士前培训通常需要4-5年的时间，其中大部分时间用于进行独立研究。学员和员工每周参加一次研究会议，讨论研究建议和进展。他们还通过参加每周一次的高级内分泌学研讨会，对他们所从事的研究领域有了深入的了解。在本次研讨会上，学生和教职员工将在为期15周的时间内对特定研究领域的关键评论和当前进展进行介绍。教师和学员每年两次参加负责任的研究指导。学员参加国家科学会议并发表论文。来自其他机构的科学家访问我们的实验室，与学生和教师进行咨询，并举办研讨会。学院实验室有能力支持多样化的培训项目，因为它们规模大、现代化且设备齐全。他们的研究装备包括各种分子生物学技术，以及蛋白质分离和表征、组织学、放射自显影、组织培养和激素测定等程序。大学还提供以下现代化的研究设施，支持生物医学研究：动物护理单位（小动物和大动物的饲养和手术设施）、免疫资源中心、蛋白质科学设施（序列测定、肽合成和质谱）、流式细胞仪设施、W. M. Keck比较和功能基因组学中心（微阵列技术、DNA测序、寡核苷酸合成、功能基因组学、高通量测序和生物信息学）、贝克曼成像技术集团和显微成像中心。为3名博士后和5名博士预科生寻求资金支持。网站性能 ======================================== 节结束 ===========================================

EXCEED THE SPACE PROVIDED. The purpose of this established and growing interdisciplinary program is to train postdoctoral and predoctoral fellows in the molecular biology, endocrinology, molecular genetics, and integrative physiology of reproduction. There are 17 postdoctoral and 51 predoctoral trainees, and they have background experience in one or more biological disciplines, such as endocrinology, reproductive biology, neurobiology and molecular biology. Fifteen faculty members, who areappointed in four discipline-related departments - Animal Sciences, Biochemistry, Molecular andIntegrative Physiology, and Veterinary Biosciences (some faculty are cross-appointed in Cell and Structural Biology) - provide great breadth and depth in research training opportunities. Current projects on all classes of reproductive hormones cover many aspects of both male and female reproductive biology. Studies are conducted on both small and large animals at the molecular, cellular, organ, and whole animal levels. Ongoing research projects relate directly to major national health-related objectives, such as regulating male and female fertility, arresting the growth of hormone- dependent mammary and prostate cancer, providing postmenopausal protection from bone demineralization, understanding the causes of and securing treatment for endometriosis and uterine fibroids, preventing prolonged and difficult delivery, and characterizing substances within the environment that disrupt the reproductive system. Postdoctoral trainees are involved principally in independent original research, and they generally complete their training in 3-4 years. Predoctoral trainees take courses in endocrinology and physiology of reproduction as well as related topics, such as biochemistry, molecular biology, immunology, and statistics before beginning independent research. The majority of the 4-5 years that are generally required to complete predoctoral training is spent conducting independent research. Trainees and staff participate in a weekly research conference to discuss research proposals and progress. They also gain a solid understanding of research areas beyond that in which they are engaged by participating weekly in an advanced endocrinology seminar. In this seminar, students and staff present critical reviews and current advances in a specific research area throughout a 15-week period. Twice each year faculty and trainees participate in instruction in the responsible conduct of research. Trainees attend and present papers at national scientific meetings. Scientists from other institutions visit our laboratories to consult with students and faculty and to present seminars. Faculty laboratories are capable of supporting a diverse training program because they are large, modern and well equipped. They are equipped for research that involves a variety of molecular biology techniques as well as procedures in protein isolation and characterization, histology, autoradiography, tissue culture, and hormone assays. The University also provides the following modern research facilities that support biomedical research: Animal Care Units (housing and surgery facilities for small and large animals), Immunological Resource Center, Protein Sciences Facility (sequence determination, peptide synthesis and mass spectrometry), Flow Cytometry Facility, W. M. Keck Center for Comparative and Functional Genomics (microarray technologies, DNA sequencing, oligonucleotide synthesis, functional genomics, high throughput sequencing, and bioinformatics), Beckman Imaging Technology Group and the Center for Microscopic Imaging. Financial support is sought for three postdoctoral and five predoctoral trainees. PERFORMANCE SITE ========================================Section End===========================================