LATE EFFECTS IN SURVIVORS OF STEM CELL TRANSPLANTATION

描述：（申请人的描述）K. Scott Baker，医学博士是一名儿科医师 大学血液和骨髓移植项目的肿瘤学家 明尼苏达州，并被任命为助理教授 儿科。 候选人的职业目标是： 1）发展 临床研究专业知识，具有扎实的临床研究基础 方法论、流行病学和生物统计学，2) 将这些活动的重点放在 造血干细胞领域以患者为导向的研究 移植（SCT），特别是移植相关并发症和晚期 效果，3）利用这些新获得的技能来实现 独立临床研究者的身份。 拟定职业 发展计划将提供全面的、多学科的、紧密的 指导、以患者为导向的研究经验。 这将在 与临床研究中获得的正式教学培训相结合 就读临床研究硕士学位课程的候选人 流行病学部。 在 Leslie Robison 博士的指导下 候选人诺玛·拉姆齐博士将启动对已故事件的调查 SCT 后长期幸存者中观察到的影响。 拟议的研究将 建立SCT的前瞻性和回顾性长期随访研究 明尼苏达大学的幸存者因系统化、协议驱动、 评估发病率、危险因素和特征 心肺、肾脏、内分泌和生殖的后期影响、质量 生活结果和第二种恶性肿瘤。 假设驱动 还将对目前的 1226 名人口进行调查 长期幸存者。 这些将包括对不同因素影响的研究 移植调理方案（全身照射、总淋巴 仅放疗和化疗）对儿童随后的后期影响， 分析治疗相关后遗症的范围和严重程度 长期跟踪的第二个十年的发展，并进行了分析 慢性移植物抗宿主病对后期效果和质量的影响 SCT 幸存者的生命。 候选人还将利用来自 正在进行的、多机构的儿童癌症幸存者研究（Robison 博士是 首席研究员）对该队列中的患者进行比较分析 接受标准化疗的患者与接受 SCT 作为治疗一部分的患者 他们的治疗。

DESCRIPTION: (Applicant's Description) K. Scott Baker, M.D. is a pediatric oncologist in the Blood and Marrow Transplant Program at the University of Minnesota, and holds an appointment as an Assistant Professor in the Department of Pediatrics. The candidates career goals are: 1) to develop clinical research expertise which has a solid foundation in clinical research methodology, epidemiology, and biostatistics, 2) to focus these activities on patient oriented research in the field of hematopoietic stem cell transplantation (SCT), specifically transplant related complications and late effects, 3) to utilize these newly acquired skills in order to achieve the status as an independent clinical investigator. The proposed career development plan will provide a comprehensive, multidisciplinary, closely mentored, patient oriented research experience. This will be accomplished in conjunction with formal didactic training in Clinical Research obtained by the candidate enrolling in the master's degree program in clinical research in the Division of Epidemiology. Under the mentorship of Dr. Leslie Robison and Dr. Norma Ramsay, the candidate will initiate investigations into the late effects seen in long-term survivors after SCT. The proposed research will establish prospective and retrospective, long-term follow-up studies of SCT survivors at the University of Minnesota for the systematic, protocol driven, evaluation of the incidence, risk factors, and characteristics of cardiopulmonary, renal, endocrine and reproductive late effects, quality of life outcomes, and second malignant neoplasms. Hypothesis driven investigations will also be undertaken in the current population of 1226 long-term survivors. These will include studies of the impact of different transplant conditioning regimens (total body irradiation, total lymphoid irradiation, and chemotherapy only) on subsequent late effects in children, an analysis of the spectrum and severity of treatment related sequelae which develop in the second decade of long-term follow-up, and an analysis of the impact that chronic graft-versus-host disease has on late effects and quality of life in SCT survivors. The candidate will also utilize data frorn the ongoing, multi-institutional, Childhood Cancer Survivor Study (Dr. Robison is Principal Investigator) for a comparative analysis of patients in that cohort receiving standard chemotherapy versus those who have undergone SCT as part of their therapy.