LATE EFFECTS IN SURVIVORS OF STEM CELL TRANSPLANTATION

描述：（申请人的描述）K. Scott Baker，医学博士是儿科 血液和骨髓移植项目的肿瘤学家， 明尼苏达州，并持有任命为助理教授在 儿科系。 候选人的职业目标是：1）发展 临床研究专业知识，在临床研究方面具有坚实的基础 方法学、流行病学和生物统计学，2）将这些活动的重点放在 造血干细胞领域的患者导向研究 移植（SCT），特别是移植相关并发症和晚期 3）利用这些新获得的技能，以实现 作为独立临床研究者。 提议的职业 发展计划将提供一个全面的，多学科的，密切 有指导的，以病人为导向的研究经验。 这将在 结合临床研究中的正式教学培训， 候选人就读于硕士学位课程的临床研究， 流行病学分部。 在莱斯利·罗宾逊博士的指导下， 诺玛·拉姆齐博士，候选人将开始调查 SCT后长期存活者中观察到的影响。 拟议的研究将 建立SCT前瞻性和回顾性长期随访研究 幸存者在明尼苏达大学的系统，协议驱动， 评估的发病率，危险因素，和特点， 心肺、肾脏、内分泌和生殖晚期效应， 生活结果，其次是恶性肿瘤。 假设驱动 调查还将在目前的1226人中进行 长期的幸存者 这些研究将包括不同的 移植预处理方案（全身照射、全身淋巴 放疗和化疗）对儿童的后期影响， 分析治疗相关后遗症的范围和严重程度， 在第二个十年的长期后续行动中， 慢性移植物抗宿主病对晚期效应和质量影响 SCT幸存者的生命。 候选人还将利用来自 正在进行的，多机构，儿童癌症幸存者研究（罗宾逊博士是 主要研究者）对该队列中的患者进行比较分析 接受标准化疗的患者与接受SCT作为 他们的治疗。

DESCRIPTION: (Applicant's Description) K. Scott Baker, M.D. is a pediatric oncologist in the Blood and Marrow Transplant Program at the University of Minnesota, and holds an appointment as an Assistant Professor in the Department of Pediatrics. The candidates career goals are: 1) to develop clinical research expertise which has a solid foundation in clinical research methodology, epidemiology, and biostatistics, 2) to focus these activities on patient oriented research in the field of hematopoietic stem cell transplantation (SCT), specifically transplant related complications and late effects, 3) to utilize these newly acquired skills in order to achieve the status as an independent clinical investigator. The proposed career development plan will provide a comprehensive, multidisciplinary, closely mentored, patient oriented research experience. This will be accomplished in conjunction with formal didactic training in Clinical Research obtained by the candidate enrolling in the master's degree program in clinical research in the Division of Epidemiology. Under the mentorship of Dr. Leslie Robison and Dr. Norma Ramsay, the candidate will initiate investigations into the late effects seen in long-term survivors after SCT. The proposed research will establish prospective and retrospective, long-term follow-up studies of SCT survivors at the University of Minnesota for the systematic, protocol driven, evaluation of the incidence, risk factors, and characteristics of cardiopulmonary, renal, endocrine and reproductive late effects, quality of life outcomes, and second malignant neoplasms. Hypothesis driven investigations will also be undertaken in the current population of 1226 long-term survivors. These will include studies of the impact of different transplant conditioning regimens (total body irradiation, total lymphoid irradiation, and chemotherapy only) on subsequent late effects in children, an analysis of the spectrum and severity of treatment related sequelae which develop in the second decade of long-term follow-up, and an analysis of the impact that chronic graft-versus-host disease has on late effects and quality of life in SCT survivors. The candidate will also utilize data frorn the ongoing, multi-institutional, Childhood Cancer Survivor Study (Dr. Robison is Principal Investigator) for a comparative analysis of patients in that cohort receiving standard chemotherapy versus those who have undergone SCT as part of their therapy.