METABOLIC SYNDROME FOLLOWING TRANSPLANT FOR LEUKEMIA

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。我们建议进行一项临床研究，以评估在接受造血细胞移植(HCT)的青少年和年轻成人白血病幸存者中，胰岛素抵抗、生长激素缺乏和其他胰岛素抵抗介质与代谢综合征发生的关系；比较HCT幸存者与普通人群中代谢综合征的患病率；并将胰岛素抵抗和代谢综合征的具体指标与年龄/性别匹配的对照组对象进行类似的研究。我们还将调查内皮损伤和其他心血管疾病的早期迹象是否在患有代谢综合征的HCT幸存者中明显比那些没有代谢综合征的人更常见。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to conduct a clinical study to evaluate the relation between insulin resistance, growth hormone deficiency and other mediators of insulin resistance, with the development of metabolic syndrome in a sample of adolescent and young adult survivors of childhood leukemia who underwent hematopoietic cell transplant (HCT); to compare the prevelance of metabolic syndrome in HCT survivors to the general population; and to compare specific measures of insulin resistance and metabolic syndrome to age/sex matched control subjects that have been studied in a similar fashion. We will also investigate whether endothelial impairment and other early signs of cardiovascular disease are significantly more prevalent among HCT survivors with metabolic syndrome, compared to those without metabolic syndrome.