METABOLIC SYNDROME FOLLOWING TRANSPLANT FOR LEUKEMIA

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。我们建议开展一项临床研究，评估胰岛素抵抗、生长激素缺乏和其他胰岛素抵抗介质与接受造血细胞移植（HCT）的青少年和青壮年儿童白血病幸存者代谢综合征发展的关系；比较HCT幸存者与普通人群中代谢综合征的患病率；并将胰岛素抵抗和代谢综合征的具体指标与年龄/性别匹配的对照受试者进行比较，这些对照受试者以类似的方式进行了研究。我们还将调查内皮损伤和其他心血管疾病的早期症状是否在有代谢综合征的HCT幸存者中比没有代谢综合征的患者更普遍。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to conduct a clinical study to evaluate the relation between insulin resistance, growth hormone deficiency and other mediators of insulin resistance, with the development of metabolic syndrome in a sample of adolescent and young adult survivors of childhood leukemia who underwent hematopoietic cell transplant (HCT); to compare the prevelance of metabolic syndrome in HCT survivors to the general population; and to compare specific measures of insulin resistance and metabolic syndrome to age/sex matched control subjects that have been studied in a similar fashion. We will also investigate whether endothelial impairment and other early signs of cardiovascular disease are significantly more prevalent among HCT survivors with metabolic syndrome, compared to those without metabolic syndrome.