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EFFECT OF SPINAL CORD STIMULATION ON CEREBRAL BLOOD FLOW

脊髓刺激对脑血流的影响

基本信息

批准号：
6692673
负责人：
OREN SAGHER
金额：
$ 18.85万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-01-25 至 2005-06-30
项目状态：
已结题

项目摘要

Spinal cord stimulation (SCS), a widely used modality for the treatment of chronic pain, is also known to have a significant vasodilator effect on peripheral vasculature. Interest in the vascular effects of SCS has resulted in its use to treat both peripheral limb ischemic and angina. Similar effects of SCS on cerebral blood flow have also been suggested. However, the significance, character and underlying mechanisms of the cerebrovascular effects of SCS remain unclear. The accompanying proposal will delineate the cerebrovascular effects of SCS in an animal model and examine the mechanism(s) that may be involved. We will also examine the feasibility of using SCS in the prevention of cerebral infarction. Specifically, we will test the following central hypotheses: I. SGS significantly enhances global cerebral blood flow (CBF) II. Cerebrovascular effects of SCS are related to changes in sympathetic tone III. Cerebrovascular effects Of SCS involve activation of brainstem/cerebellar vasomotor centers IV. Trigeminovascular innervation of cerebral vasculature mediates SCS effects on CBF V. SCS has a neuroprotective effect in the setting of focal cerebral ischemic We will utilize an in vivo model of SCS and CBF measurement in rats in order to obtain information about the magnitude, time course, and spatial characteristics of CBF changes induced by SCS. Using this model, we will also investigate the effects of SCS on stroke induced by focal cerebral ischemic. An understanding of the mechanisms involved in the cerebrovascular effects of SCS has direct ramifications in the treatment of conditions where cerebral blood flow is compromised, such as stroke, cerebral vasospasm and traumatic brain injury.

脊髓刺激（SCS）是一种广泛用于治疗慢性疼痛的方式，也已知对外周血管系统具有显著的血管扩张作用。对SCS的血管效应的关注导致其用于治疗外周肢体缺血性和心绞痛。还提出了SCS对脑血流量的类似影响。然而，SCS脑血管效应的意义、特征和机制尚不清楚。随附的建议将描述SCS在动物模型中的脑血管效应，并检查可能涉及的机制。我们还将研究使用SCS预防脑梗死的可行性。具体而言，我们将测试以下中心假设：I。SGS显着增加全球脑血流量（CBF）II。SCS的脑血管效应与交感神经张力III的变化有关。SCS的脑血管效应涉及脑干/小脑血管中枢IV的激活。脑血管系统的三叉神经血管神经支配介导SCS对CBF V的影响。SCS在局灶性脑缺血的情况下具有神经保护作用。我们将利用大鼠SCS和CBF测量的体内模型，以获得关于SCS诱导的CBF变化的幅度、时间过程和空间特征的信息。利用该模型，我们还将研究SCS对局灶性脑缺血诱导的卒中的影响。对SCS脑血管效应相关机制的理解对脑血流受损的疾病（如中风、脑血管痉挛和创伤性脑损伤）的治疗有直接影响。