EFFECT OF SPINAL CORD STIMULATION ON CEREBRAL BLOOD FLOW

脊髓刺激（SCS）是一种广泛用于治疗慢性疼痛的方式，也被认为对周围血管系统有显著的血管扩张作用。对SCS血管作用的兴趣导致其用于治疗外周肢体缺血和心绞痛。SCS对脑血流也有类似的影响。然而，SCS对脑血管作用的意义、特点和潜在机制尚不清楚。随附的提案将描述SCS在动物模型中的脑血管作用，并研究可能涉及的机制。我们还将探讨利用SCS预防脑梗死的可行性。具体而言，我们将检验以下中心假设：1 . SGS显著提高脑血流（CBF） 2。SCS的脑血管作用与交感神经张力III的改变有关。脑血管作用涉及脑干/小脑血管运动中枢的激活IV.脑血管的三叉神经支配介导SCS对脑血流的作用V. SCS在局灶性脑缺血情况下具有神经保护作用我们将利用体内SCS模型和大鼠CBF测量来获取SCS诱导的CBF变化的幅度、时间过程和空间特征。利用该模型，我们还将研究SCS对局灶性脑缺血引起的脑卒中的影响。了解SCS对脑血管的作用机制对脑血流受损的治疗有直接的影响，如中风、脑血管痉挛和创伤性脑损伤。

Spinal cord stimulation (SCS), a widely used modality for the treatment of chronic pain, is also known to have a significant vasodilator effect on peripheral vasculature. Interest in the vascular effects of SCS has resulted in its use to treat both peripheral limb ischemic and angina. Similar effects of SCS on cerebral blood flow have also been suggested. However, the significance, character and underlying mechanisms of the cerebrovascular effects of SCS remain unclear. The accompanying proposal will delineate the cerebrovascular effects of SCS in an animal model and examine the mechanism(s) that may be involved. We will also examine the feasibility of using SCS in the prevention of cerebral infarction. Specifically, we will test the following central hypotheses: I. SGS significantly enhances global cerebral blood flow (CBF) II. Cerebrovascular effects of SCS are related to changes in sympathetic tone III. Cerebrovascular effects Of SCS involve activation of brainstem/cerebellar vasomotor centers IV. Trigeminovascular innervation of cerebral vasculature mediates SCS effects on CBF V. SCS has a neuroprotective effect in the setting of focal cerebral ischemic We will utilize an in vivo model of SCS and CBF measurement in rats in order to obtain information about the magnitude, time course, and spatial characteristics of CBF changes induced by SCS. Using this model, we will also investigate the effects of SCS on stroke induced by focal cerebral ischemic. An understanding of the mechanisms involved in the cerebrovascular effects of SCS has direct ramifications in the treatment of conditions where cerebral blood flow is compromised, such as stroke, cerebral vasospasm and traumatic brain injury.