EFFECT OF SPINAL CORD STIMULATION ON CEREBRAL BLOOD FLOW

脊髓刺激(SCS)是一种广泛用于治疗慢性疼痛的方法，也被认为对周围血管具有显著的血管扩张作用。人们对SCS的血管效应感兴趣，因此将其用于治疗周围肢体缺血和心绞痛。SCS对脑血流量也有类似的影响。然而，SCS的脑血管效应的意义、特征和潜在机制尚不清楚。随附的提案将描述SCS对动物模型的脑血管影响，并研究可能涉及的机制(S)。我们还将研究使用SCS预防脑梗塞的可行性。具体地说，我们将检验以下中央假设：I.SGS显著增加全球脑血流量(CBF)II.SCS的脑血管效应与交感神经张力的变化有关。SCS的脑血管效应涉及脑干/小脑血管运动中心的激活IV.脑血管的三叉神经支配介导SCS对CBF的影响.SCS在局灶性脑缺血的背景下具有神经保护作用我们将利用SCS和CBF的在体模型来获得SCS引起的CBF变化的幅度、时间过程和空间特征的信息。利用该模型，我们还将研究SCS对局灶性脑缺血所致卒中的影响。了解SCS的脑血管效应所涉及的机制对于治疗脑血流受损的情况具有直接的指导意义，如中风、脑血管痉挛和创伤性脑损伤。

Spinal cord stimulation (SCS), a widely used modality for the treatment of chronic pain, is also known to have a significant vasodilator effect on peripheral vasculature. Interest in the vascular effects of SCS has resulted in its use to treat both peripheral limb ischemic and angina. Similar effects of SCS on cerebral blood flow have also been suggested. However, the significance, character and underlying mechanisms of the cerebrovascular effects of SCS remain unclear. The accompanying proposal will delineate the cerebrovascular effects of SCS in an animal model and examine the mechanism(s) that may be involved. We will also examine the feasibility of using SCS in the prevention of cerebral infarction. Specifically, we will test the following central hypotheses: I. SGS significantly enhances global cerebral blood flow (CBF) II. Cerebrovascular effects of SCS are related to changes in sympathetic tone III. Cerebrovascular effects Of SCS involve activation of brainstem/cerebellar vasomotor centers IV. Trigeminovascular innervation of cerebral vasculature mediates SCS effects on CBF V. SCS has a neuroprotective effect in the setting of focal cerebral ischemic We will utilize an in vivo model of SCS and CBF measurement in rats in order to obtain information about the magnitude, time course, and spatial characteristics of CBF changes induced by SCS. Using this model, we will also investigate the effects of SCS on stroke induced by focal cerebral ischemic. An understanding of the mechanisms involved in the cerebrovascular effects of SCS has direct ramifications in the treatment of conditions where cerebral blood flow is compromised, such as stroke, cerebral vasospasm and traumatic brain injury.