Identification of regulatory genomic networks underlying skin ageing

识别皮肤衰老背后的调控基因组网络

• 批准号: 2512524
• 金额: --
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2512524
• 关键词: Identification; regulatory; genomic; networks; underlying

Deciphering which mRNA or epigenetic changes with age contribute to ageing rather than are aconsequence of ageing is extremely difficult. However, DNA sequence variants that associate with ageing traits are likely to be causal, because genetic variants do not change with age. How genetic variants precisely affect regulation of nearby genes and potential downstream targets needs further study. Hence, unravelling the complex network of epigenetic and expression pathways associated with ageing-related genetic variation is useful in determining how causal gene variants influence age-related processes in cells.

破译哪些mRNA或表观遗传变化随着年龄的增长导致了衰老，而不是衰老的结果，是非常困难的。然而，与衰老特征相关的DNA序列变异可能是因果关系，因为基因变异不会随着年龄而改变。遗传变异如何精确影响邻近基因和潜在下游靶点的调控还有待进一步研究。因此，揭示与衰老相关的遗传变异相关的表观遗传和表达途径的复杂网络，有助于确定因果基因变异如何影响细胞中与年龄相关的过程。