Atomic Biomagnetometer

原子生物磁强计

• 批准号: 6922577
• 负责人: THAD G WALKER
• 金额: $ 21.23万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-22 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6922577
• 关键词: bioimaging /biomedical imaging; biomagnetism measurement; biomedical equipment development; cardiography; clinical research; embryo /fetus monitoring; noninvasive diagnosis; optics; phantom model; rubidium

DESCRIPTION (provided by applicant): The long-term goal of this research program is to develop an optical magnetometer for use in fetal magnetocardiography (fMCG) and fetal magnetoencephalography {fMEG) systems. We believe that the proposed magnetometer, based on a major recent discovery,represents the first viable alternative to SQUID magnetometers; thus,the potential impact of the research on the field of biomagnetism is enormous. Utilization of fMCG and fMEG has been limited by the high cost of acquisition and maintenance associated with SQUID technology. The optical magnetometer can mitigate these disadvantages while n maintaining or even surpassing the magnetic field sensitivity of SQUID magnetometers. Thus far only the high sensitivity of the device has been demonstrated. The short-term goal of the research is to construct a device that is practical for human studies, while maintaining the high magnetic field sensitivity. The specific aims are: 1. To build a optical magnetometer/gradiometer that utilizes rubidium atoms and achieves a magnetic field sensitivity 10A-14 T/(Hz)A1/2. 2. To construct a miniaturized prototype magnetometer that would be practical for fetal n magnetocardiography. 3. To evaluate the performance of the magnetometer by assessing its signal and noise characteristics and by conducting phantom studies. 4. To justify classification of the magnetometer as a nonsignificant risk by assessing and eliminating n potential safety hazards.

描述（由申请人提供）： 该研究计划的长期目标是开发一种用于胎儿心磁图 (fMCG) 和胎儿脑磁图 (fMEG) 系统的光学磁力计。我们相信，所提出的磁力计基于最近的一项重大发现，代表了 SQUID 磁力计的第一个可行替代方案；因此，该研究对生物磁学领域的潜在影响是巨大的。 fMCG 和 fMEG 的利用受到与 SQUID 技术相关的高采购和维护成本的限制。光学磁力计可以减轻这些缺点，同时保持甚至超越SQUID磁力计的磁场灵敏度。到目前为止，仅证明了该设备的高灵敏度。该研究的短期目标是构建一种适用于人类研究的装置，同时保持高磁场灵敏度。具体目标是： 1. 构建利用铷原子的光学磁力计/梯度计，磁场灵敏度达到10A-14 T/(Hz)A1/2。 2. 构建适用于胎儿心磁图的小型化原型磁力计。 3. 通过评估磁力计的信号和噪声特性以及进行模型研究来评估磁力计的性能。 4. 通过评估和消除潜在的安全隐患，证明将磁力计分类为非重大风险的合理性。