Atomic Magnetometer For Fetal Biomagnetism

胎儿生物磁力原子磁力计

• 批准号: 8506614
• 负责人: THAD G WALKER
• 金额: $ 28.6万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8506614
• 关键词: Adult; Arrhythmia; Detection; Development; Disadvantaged; Environment; Fetal Heart; Fetal Monitoring; Fetal Mortality Statistics; Fetus; Goals; Grant; Magnetism; Magnetoencephalography; Magnetometries; Maintenance; Methodology; Methods; Optics; Pregnancy; Research; Research Personnel; Signal Transduction; System; Technology; Testing; base; biomagnetism; computerized data processing; cost; detector; encephalography; fetal; fetus at risk; heart rhythm; human subject; improved; magnetic field; new technology; novel; operation; preclinical study; programs; public health relevance

DESCRIPTION (provided by applicant): The long-term goal of this research program is to develop an optical magnetometer array for use in fetal magnetocardiography (fMCG) and fetal magneto-encephalography (fMEG) systems. The proposed magnetometer, based on recent advances in magnetometer technology, represents the first viable alternative to SQUID magnetometers; thus, the potential impact of the research on the field of biomagnetism is enormous. Utilization of fMCG and fMEG has been limited by the high cost of acquisition and maintenance associated with SQUID technology. The atomic magnetometer can mitigate these disadvantages while maintaining or even surpassing the magnetic field sensitivity of SQUID magnetometers. A novel, four-channel atomic biomagnetometer array was recently demonstrated for adult and fetal MCG studies. The next steps are to refine it for use in conventional magnetically shielded rooms and to extend its capabilities to inexpensive shielding geometries. The specific aims of this project are: 1. to demonstrate a 9-channel atomic magnetometer array for direct comparison to commercial SQUIDs for detection of signals from 20 week gestation period fetuses. 2. To extend the bandwidth and dynamic range of the atomic magnetometer for use in inexpensive shielding environments. 3. To make pre-clinical studies of at-risk fetuses with the magnetometer array. To achieve these aims, the researchers will investigate new modes of operation of the magnetometer that improve its bandwidth and dynamic range. New data processing methodologies will be considered, and the developments will be tested with human subjects.

描述(申请人提供)：该研究计划的长期目标是开发一种用于胎儿心磁图(FMCG)和胎儿脑磁图(FMEG)系统的光学磁强计阵列。建议的磁强计基于磁强计技术的最新进展，是第一个可行的SQUID磁强计的替代方案；因此，这项研究对生物磁学领域的潜在影响是巨大的。由于与SQUID技术相关的高昂的获取和维护成本，FMCG和FMEG的使用一直受到限制。原子磁强计可以在保持甚至超过SQUID磁强计的磁场灵敏度的同时，缓解这些缺点。最近，一种新型的四通道原子生物磁强计阵列被展示用于成人和胎儿的MCG研究。下一步是改进它，用于传统的磁屏蔽房间，并将其能力扩展到廉价的屏蔽几何结构。该项目的具体目标是：1.展示一种9通道原子磁力计阵列，用于直接与商用SQUID进行比较，以检测20周孕期胎儿的信号。2.扩展原子磁强计的带宽和动态范围，以用于廉价的屏蔽环境。3.利用磁强计阵列对高危胎儿进行临床前研究。为了实现这些目标，研究人员将研究磁强计的新工作模式，以改善其带宽和动态范围。将考虑新的数据处理方法，并将在人体受试者中测试这些发展。