Training in Hypersensitivity and Cancer Immunology

超敏反应和癌症免疫学培训

• 批准号: 6940592
• 负责人: DANIEL H CONRAD
• 金额: $ 16.36万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6940592
• 关键词: Training; Hypersensitivity; Cancer; Immunology

DESCRIPTION (provided by applicant): The goal of this training program continues to be training health scientists for research, service and education in biomedical institutions, especially comprehensive health science centers. The research training is directed by a major advisor and advisory committee and involves participation in appropriate courses, peer evaluation and scientific interchange in various weekly research meetings, journal clubs, research seminars, and participation in national conferences and meetings. A major strength of this program is that it provides training in a multi-disciplinary research environment in association with development of didactic knowledge through formal instructions in immunology, biochemistry, molecular genetics and other fields. This training program is for five predoctoral trainees and fits into the strength of this department, that being expertise in hypersensitivity, antigen processing and cancer immunology mechanisms. Areas of research emphasis available to trainees include: molecular and biochemical analysis of cell bound and shed IgE receptors on mast cells and lymphocytes; IgE and IgE immune complex triggering of mast cell differentiation and cytokine production; mechanisms of mast cell differentiation, structure and function of mast cell derived proteases; definition of the mechanisms by which cannabinoids and drugs of abuse alter immune functionality especially as it relates to host resistance to virus infections; structure and biochemistry of follicular dendritic cells (FDC) and interaction of FDC with IgE and IgE immune complexes; involvement of FDCs in HIV pathogenesis; role of CD44 and immunotoxins in activation induced cell death; tumor evasion mechanisms and tumor vaccine strategies; mucosal B cell differentiation, especially roles of TGF.; mechanisms by which highly-pathogenic ameba such as Naegleria fowleri develop resistance to complement-mediated lysis; biochemistry of antigen processing including intracellular trafficking of immune complexes; biochemical events involved in the activation of macrophages by LPS and effect of PLA2 on macrophage function;. Anticipated duration of training is 5 years with a maximum of three years of support through this training grant. Evidence for a strong involvement in collaborative research is seen in the joint publications, the involvement in the general immunology curricula and in the Cancer Center Core operation. The participating faculty represent an exceptionally strong and focused community of immunologists that will continue to provide an excellent environment for training.

描述（由申请人提供）：该培训计划的目标仍然是培训卫生科学家在生物医学机构，特别是综合健康科学中心进行研究，服务和教育。研究培训由一个主要的顾问和咨询委员会指导，包括参加适当的课程，同行评价和各种每周研究会议，期刊俱乐部，研究研讨会的科学交流，以及参加全国性会议。该计划的一个主要优势是，它通过免疫学，生物化学，分子遗传学和其他领域的正式指导，提供与教学知识发展相关的多学科研究环境中的培训。该培训计划是为五名博士前学员，并符合本部门的实力，即在超敏反应，抗原加工和癌症免疫学机制的专业知识。研究重点领域包括：肥大细胞和淋巴细胞上细胞结合和脱落IgE受体的分子和生物化学分析; IgE和IgE免疫复合物触发肥大细胞分化和细胞因子产生;肥大细胞分化机制，肥大细胞衍生蛋白酶的结构和功能;确定大麻素和滥用药物改变免疫功能的机制，特别是与宿主对病毒感染的抵抗力有关的机制;滤泡树突状细胞（FDC）的结构和生物化学以及FDC与IgE和IgE免疫复合物的相互作用; FDC在HIV发病机制中的参与; CD 44和免疫毒素在活化诱导的细胞死亡中的作用;肿瘤逃避机制和肿瘤疫苗策略;粘膜B细胞分化，特别是TGF的作用;高致病性阿米巴如福氏耐格里阿米巴产生对补体介导的裂解的抗性的机制;抗原加工的生物化学，包括免疫复合物的细胞内运输;参与LPS激活巨噬细胞的生物化学事件和PLA 2对巨噬细胞功能的影响;。预计培训时间为5年，最多可通过培训补助金获得3年的支助。在联合出版物，参与一般免疫学课程和癌症中心核心业务中，可以看到强烈参与合作研究的证据。参与的教师代表了一个非常强大和专注的免疫学家社区，将继续提供良好的培训环境。