Training in Hypersensitivity and Cancer Immunology

描述（由申请人提供）：该培训计划的目标仍然是为生物医学机构，特别是综合卫生科学中心的研究，服务和教育培养卫生科学家。研究训练由一名主要顾问和咨询委员会指导，包括参加适当的课程、同行评价和各种每周研究会议、期刊俱乐部、研究讨论会的科学交流，以及参加国家会议和会议。该项目的一个主要优势是，它提供了一个多学科的研究环境，通过在免疫学、生物化学、分子遗传学和其他领域的正式指导，与教学知识的发展相关联的培训。该培训项目为5名博士预科生，适合本部门的优势，在超敏反应，抗原加工和癌症免疫机制方面具有专长。可提供给学员的研究重点领域包括：肥大细胞和淋巴细胞的细胞结合和脱落IgE受体的分子和生化分析；IgE和IgE免疫复合物触发肥大细胞分化和细胞因子的产生肥大细胞分化机制及肥大细胞源性蛋白酶的结构和功能确定大麻素和滥用药物改变免疫功能的机制，特别是与宿主对病毒感染的抵抗力有关的机制；滤泡树突状细胞（follicular dendritic cells， FDC）的结构、生化及与IgE及IgE免疫复合物的相互作用；fdc参与HIV发病机制；CD44和免疫毒素在活化诱导细胞死亡中的作用肿瘤逃避机制及肿瘤疫苗策略粘膜B细胞分化，特别是TGF的作用；高致病性阿米巴（如福氏奈格氏杆菌）对补体介导的裂解产生抗性的机制；抗原加工的生物化学，包括免疫复合物的细胞内运输；脂多糖激活巨噬细胞的生化事件及PLA2对巨噬细胞功能的影响；预计培训期限为5年，通过这项培训补助金提供最多3年的支助。在联合出版物中，在普通免疫学课程和癌症中心核心操作中，可以看到强烈参与合作研究的证据。参与的教师代表了一个非常强大和专注的免疫学家社区，他们将继续为培训提供良好的环境。

DESCRIPTION (provided by applicant): The goal of this training program continues to be training health scientists for research, service and education in biomedical institutions, especially comprehensive health science centers. The research training is directed by a major advisor and advisory committee and involves participation in appropriate courses, peer evaluation and scientific interchange in various weekly research meetings, journal clubs, research seminars, and participation in national conferences and meetings. A major strength of this program is that it provides training in a multi-disciplinary research environment in association with development of didactic knowledge through formal instructions in immunology, biochemistry, molecular genetics and other fields. This training program is for five predoctoral trainees and fits into the strength of this department, that being expertise in hypersensitivity, antigen processing and cancer immunology mechanisms. Areas of research emphasis available to trainees include: molecular and biochemical analysis of cell bound and shed IgE receptors on mast cells and lymphocytes; IgE and IgE immune complex triggering of mast cell differentiation and cytokine production; mechanisms of mast cell differentiation, structure and function of mast cell derived proteases; definition of the mechanisms by which cannabinoids and drugs of abuse alter immune functionality especially as it relates to host resistance to virus infections; structure and biochemistry of follicular dendritic cells (FDC) and interaction of FDC with IgE and IgE immune complexes; involvement of FDCs in HIV pathogenesis; role of CD44 and immunotoxins in activation induced cell death; tumor evasion mechanisms and tumor vaccine strategies; mucosal B cell differentiation, especially roles of TGF.; mechanisms by which highly-pathogenic ameba such as Naegleria fowleri develop resistance to complement-mediated lysis; biochemistry of antigen processing including intracellular trafficking of immune complexes; biochemical events involved in the activation of macrophages by LPS and effect of PLA2 on macrophage function;. Anticipated duration of training is 5 years with a maximum of three years of support through this training grant. Evidence for a strong involvement in collaborative research is seen in the joint publications, the involvement in the general immunology curricula and in the Cancer Center Core operation. The participating faculty represent an exceptionally strong and focused community of immunologists that will continue to provide an excellent environment for training.