A Spiking Model of Hippocampus for Guiding Behavior

描述(由申请人提供)：建议的研究重点是开发一个详细和现实的模型，说明在特定行为任务中，海马体、内嗅觉皮质、前额叶皮质和腹侧被盖区的神经放电模式如何调节目标导向行为。这些项目探索了目标激活、反应选择和情景记忆对指导行为的交互作用。了解这些动机行为的过程对于理解药物成瘾过程应该被证明是重要的。特别是，这项工作允许对许多相互作用区域内谷氨酸、GABA能胆碱和多巴胺能过程的变化如何影响成瘾行为进行建模。这项拟议的研究将进一步开发现有的软件，允许在虚拟环境中的神经模拟和虚拟大鼠的行为之间建立直接接口，一个同时受到行为功能和生物现实结构要求限制的模型。神经模拟使用基于节律场电位(EEG)和单个神经元的放电模式(单位记录)的大量生理数据的动力学。这里提出的研究将涉及三组人之间的持续互动： 1.爱丁堡的这个小组(Robert Cannon和Nigel Goddard)将提供一个灵活的、基于图形的模拟程序包(Catacomb)的持续开发，该程序包允许构建神经模拟，以指导虚拟大鼠在各种不同的实验任务中的行为，包括空间记忆任务和操作任务。 2.Hasselmo小组将继续模拟海马体、内嗅觉皮质、前额叶皮质和腹侧被盖区如何参与行为任务中的目标定向运动。这项工作将在生理相互作用的假设基础上，产生关于相对于o行为和相对于theta节律的脑电的尖峰时刻的明确的实验预测。 3.Eichenbaum小组将分析空间交替任务的数据，以测试模拟对行为过程中尖峰时间的具体预测。 该项目将与不列颠哥伦比亚大学Hasselmo实验室和Kantak实验室之间的单独合作进行协同互动，重点是对药物自我给药现象的实验研究中使用的操作员任务进行建模，这项工作得到了NIDA先前拨款的补充资金的支持。

DESCRIPTION (provided by applicant): The proposed research focuses on development of a detailed and realistic model of how neural firing patterns in the hippocampus, entorhinal cortex, prefrontal cortex and ventral tegmental area mediate goal directed behavior in specific behavioral tasks. These projects explore the interaction of goal activation, response selection and episodic memory for guiding behavior. Understanding these processes of motivated behavior should prove important for understanding the drug addiction processes. In particular this work allows modeling of how alterations in glutamatergic, GABAergic cholinergic and dopaminergic processes within numerous interacting regions could influence addictive behavior. The proposed research will further develop existing software that allows a direct interface between a neural simulation and behavior of a virtual rat in a virtual environment, a model simultaneously constrained by requirements about behavioral function and biologically realistic structure. The neural simulation uses dynamics based on extensive physiological data on rhythmic field potentials (EEG) and firing patterns of individual neurons (unit recording). The research proposed here will involve a continuous interaction between three groups: 1. The group in Edinburgh (Robert Cannon and Nigel Goddard) will provide ongoing development of a flexible, graphics based simulation package (CATACOMB), which allows construction of neural simulations for guiding behavior of a virtual rat in a variety of different experimental tasks, including spatial memory tasks and operant tasks. 2. The Hasselmo group will continue development of simulations of how the hippocampus, entorhinal cortex, prefrontal cortex and ventral tegmental area are involved in goal directed movements in behavioral tasks. This work will generate clear experimental predictions about the timing of spikes relative o behavior and relative to theta rhythm EEG based on hypotheses about the physiological interaction. 3. The Eichenbaum group will analyze data from a spatial alternation task to test specific predictions of the simulation about the timing of spikes during behavior. This project will have a synergistic interaction with a separate collaboration between the Hasselmo and Kantak laboratories at B.U., which focuses on modeling operant tasks used in experimental studies of drug self-administration phenomena, in work supported by a supplement to a previous grant from NIDA.