Egocentric and Allocentric Spatial Coding in Cortex

皮质中的自我中心和异中心空间编码

• 批准号: 10205980
• 负责人: Michael E Hasselmo
• 金额: $ 50.14万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-20 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10205980
• 关键词: Address; Applications Grants; Behavior; Brain; Cells; Code; Cognition; Cognitive; Cues; Darkness; Data; Dimensions; Drops; Environment; Generations; Goals; Grant; Head; Impairment; Individual; Laboratories; Light; Link; Location; Medial; Mental disorders; Modeling; Motion; Nature; Neurons; Pattern; Play; Population; Positioning Attribute; Property; Rattus; Rewards; Role; Running; Sensory; Shapes; Slice; Speed; Structure; Testing; Theta Rhythm; Time; Visual; awake; cognitive function; entorhinal cortex; experimental study; nervous system disorder; neurophysiology; novel; optogenetics; predictive modeling; relating to nervous system; response; sensory input; way finding

PROJECT SUMMARY/ABSTRACT The projects proposed in this new grant address the properties of spatial coding in cortical regions. Representations of spatial location are important for a broad range of cognitive functions, including the planning of goal-directed navigation. This grant proposes specific experiments to test modeling predictions about the existence of egocentric representations of boundaries and coding of running speed relevant to the formation of allocentric spatial representations in cortical structures. Specific Aim #1: Recordings of the neural spiking activity in retrosplenial cortex and entorhinal cortex will test the hypothesis that cortical regions must code the position of environmental boundaries in egocentric coordinates. This prediction arose from models of the formation of allocentric representations of boundaries which require input from an egocentric, view-centered coding of environmental boundaries. Experiments will extend preliminary data from this lab showing egocentric coding of boundaries in retrosplenial cortex. Models show that egocentric boundary cells could be combined with head direction input to code allocentric boundary position, which can drive coding of spatial location. Further experiments will test the influence of environmental boundaries on spiking activity in the entorhinal cortex and retrospenial cortex, including testing the influence of manipulations of the shape of the environment, the insertion of new boundaries and different reward locations, recordings in darkness, and testing coexistence of egocentric coding with allocentric coding by head direction cells. This experimental testing of the predictions from models will provide an important link for building our understanding of the coding of space for cognitive processing. Specific Aim #2: Recordings of neural spiking activity in retrosplenial cortex and entorhinal cortex will test the complementary hypothesis that coding of running speed also plays a role in generation of representations of spatial location, and how the coding of running speed varies over different time courses and may depend on sensory input from boundaries. Experiments will include analysis of the coding of running speed at different spatial scales in entorhinal cortex and retrosplenial cortex ranging from one second to many minutes. The time course will also be analyzed in experiments exploring the change in running speed representations when barrier features are obscured by darkness. This aim also includes whole cell patch recording in slices to analyze the time course of intrinsic spiking activity relevant to the circuit dynamics for coding of speed and location. Finally, optogenetic inactivation of specific populations of neurons in medial septum will test how inputs regulate the coding of spatial location and speed by neurons in the medial entorhinal cortex. These experiments will contribute to our understanding of the dynamics of cortical circuits that underlie the formation of allocentric spatial representations important to many aspects of cortical cognitive processing, including the planning of goal-directed behavior.

项目概要/摘要 这项新拨款中提出的项目解决了皮质区域空间编码的特性。 空间位置的表示对于广泛的认知功能很重要，包括 目标导向导航的规划。这笔赠款提出了具体的实验来测试建模预测 关于边界的自我中心表示和与跑步速度相关的编码的存在 皮质结构中异中心空间表征的形成。 具体目标#1：将测试压后皮层和内嗅皮层神经尖峰活动的记录 皮质区域必须以自我为中心编码环境边界位置的假设 坐标。这一预测源于边界异中心表示形成的模型 这需要来自以自我为中心、以观点为中心的环境边界编码的输入。实验将 扩展该实验室的初步数据，显示压后皮质边界的自我中心编码。型号 表明自我中心边界细胞可以与头部方向输入相结合来编码异中心边界 位置，可以驱动空间位置的编码。进一步的实验将测试环境的影响 内嗅皮层和阴茎后皮层尖峰活动的边界，包括测试 操纵环境的形状，插入新的边界和不同的奖励位置， 在黑暗中进行录音，并通过头部方向测试自我中心编码与异中心编码的共存 细胞。对模型预测的实验测试将为构建我们的 了解认知处理的空间编码。 具体目标#2：记录压后皮质和内嗅皮质的神经尖峰活动将测试 补充假设，跑步速度的编码也在生成表示中发挥作用 空间位置，以及跑步速度的编码如何在不同的时间过程中变化，并且可能取决于 来自边界的感觉输入。实验将包括分析不同运行速度的编码 内嗅皮层和压后皮层的空间尺度从一秒到几分钟不等。时间 当然也将在实验中进行分析，探索运行速度表示的变化 屏障特征被黑暗遮蔽。该目标还包括切片中的全细胞贴片记录 分析与电路动态相关的内在尖峰活动的时间过程，以进行速度编码和 地点。最后，内侧隔膜中特定神经元群的光遗传学失活将测试如何 输入调节内侧内嗅皮层神经元对空间位置和速度的编码。这些 实验将有助于我们理解构成其形成基础的皮层回路的动力学 异中心空间表征对于皮层认知处理的许多方面都很重要，包括 规划目标导向的行为。