A Spiking Model of Hippocampus for Guiding Behavior

指导行为的海马尖峰模型

• 批准号: 6641875
• 负责人: Michael E Hasselmo
• 金额: $ 24.9万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6641875
• 关键词: action potentials; behavior test; behavioral /social science research tag; computational neuroscience; computer human interaction; computer program /software; computer simulation; computer system design /evaluation; electroencephalography; electrophysiology; entorhinal cortex; goal oriented behavior; hippocampus; interdisciplinary collaboration; memory; model design /development; motivation; neural transmission; neurophysiology; prefrontal lobe /cortex; tegmentum

DESCRIPTION (provided by applicant): The proposed research focuses on development of a detailed and realistic model of how neural firing patterns in the hippocampus, entorhinal cortex, prefrontal cortex and ventral tegmental area mediate goal directed behavior in specific behavioral tasks. These projects explore the interaction of goal activation, response selection and episodic memory for guiding behavior. Understanding these processes of motivated behavior should prove important for understanding the drug addiction processes. In particular this work allows modeling of how alterations in glutamatergic, GABAergic cholinergic and dopaminergic processes within numerous interacting regions could influence addictive behavior. The proposed research will further develop existing software that allows a direct interface between a neural simulation and behavior of a virtual rat in a virtual environment, a model simultaneously constrained by requirements about behavioral function and biologically realistic structure. The neural simulation uses dynamics based on extensive physiological data on rhythmic field potentials (EEG) and firing patterns of individual neurons (unit recording). The research proposed here will involve a continuous interaction between three groups: 1. The group in Edinburgh (Robert Cannon and Nigel Goddard) will provide ongoing development of a flexible, graphics based simulation package (CATACOMB), which allows construction of neural simulations for guiding behavior of a virtual rat in a variety of different experimental tasks, including spatial memory tasks and operant tasks. 2. The Hasselmo group will continue development of simulations of how the hippocampus, entorhinal cortex, prefrontal cortex and ventral tegmental area are involved in goal directed movements in behavioral tasks. This work will generate clear experimental predictions about the timing of spikes relative o behavior and relative to theta rhythm EEG based on hypotheses about the physiological interaction. 3. The Eichenbaum group will analyze data from a spatial alternation task to test specific predictions of the simulation about the timing of spikes during behavior. This project will have a synergistic interaction with a separate collaboration between the Hasselmo and Kantak laboratories at B.U., which focuses on modeling operant tasks used in experimental studies of drug self-administration phenomena, in work supported by a supplement to a previous grant from NIDA.

描述（由申请人提供）：拟议的研究重点是开发一个详细而现实的模型，说明海马体、内嗅皮层、前额叶皮层和腹侧被盖区的神经放电模式如何介导特定行为任务中的目标导向行为。这些项目探索目标激活、反应选择和情景记忆之间的相互作用以指导行为。了解这些动机行为的过程对于理解毒瘾过程应该很重要。特别是，这项工作可以模拟众多相互作用区域内谷氨酸能、GABA能胆碱能和多巴胺能过程的改变如何影响成瘾行为。拟议的研究将进一步开发现有的软件，该软件允许虚拟环境中虚拟大鼠的神经模拟和行为之间的直接接口，该模型同时受到行为功能和生物现实结构要求的约束。神经模拟使用基于节律场电位 (EEG) 和单个神经元放电模式（单位记录）的广泛生理数据的动力学。这里提出的研究将涉及三个群体之间的持续互动： 1. 爱丁堡的小组（Robert Cannon 和 Nigel Goddard）将提供一个灵活的、基于图形的模拟包（CATACOMB）的持续开发，该包允许构建神经模拟，以指导虚拟老鼠在各种不同实验任务中的行为，包括空间记忆任务和操作任务。 2. Hasselmo 小组将继续开发海马体、内嗅皮层、前额叶皮层和腹侧被盖区如何参与行为任务中目标导向运动的模拟。这项工作将基于生理相互作用的假设，对相对于行为和 θ 节律脑电图的尖峰时间产生清晰的实验预测。 3. Eichenbaum 小组将分析空间交替任务的数据，以测试模拟对行为期间尖峰时间的具体预测。 该项目将与 B.U. 的 Hasselmo 和 Kantak 实验室之间的单独合作进行协同互动，重点是对药物自我给药现象实验研究中使用的操作任务进行建模，这项工作得到了 NIDA 先前拨款的补充支持。