Conference--Chemokines and Chemokine Receptors

趋化因子是一种趋化细胞因子，通过激活特定的G蛋白偶联受体诱导细胞定向迁移。这个由大约50个细胞因子和大约20个受体组成的系统在哺乳动物免疫系统中白细胞的发育、动态平衡和激活方面发挥着特别重要的作用。 趋化因子决定了一系列人类疾病中组织炎症反应的性质，并代表了有吸引力的新治疗靶点。趋化因子也可以吸引和刺激非免疫细胞，如肿瘤细胞、神经元和血管。本次会议将讨论趋化因子领域中尚未回答的主要问题，包括趋化因子如何调节淋巴系统的发育，细胞如何感知趋化因子的梯度，趋化因子信号通路的性质，趋化因子如何放大免疫介导的疾病，以及干扰趋化因子信号传递是否可以治疗或预防疾病。本课程将着重介绍体内趋化因子功能的系统生物学方法，并将扩展到体内趋化因子系统与其他调节系统的调节和相互关系。定向细胞 迁移是正常发育、体内平衡以及身体对感染和癌症的反应所必需的过程。细胞异常迁移是自身免疫性和炎症性疾病的重要组成部分。趋化因子和趋化因子受体是体内控制细胞迁移的蛋白质。更好地了解趋化因子系统是如何控制细胞运动的，将导致增加细胞运输的新方法，以对抗传染病和癌症，提高疫苗效力，并抑制自身免疫性和炎症性疾病中细胞在组织中的病理性募集。

Chemokines are chemotactic cytokines that induce the directed migration of cells by activating specific G protein-coupled receptors. This system of approximately 50 cytokines and approximately 20 receptors plays a particularly prominent role in development, homeostasis and activation of leukocytes in the mammalian immune system. Chemokines determine the nature of the tissue inflammatory response in a wide range of human diseases and represent attractive new therapeutic targets. Chemokines may also attract and stimulate non-immune cells, such as tumor cells, neurons and blood vessels. This meeting will address major unanswered questions in the chemokine field including how Chemokines regulate lymphoid development, how cells sense chemokine gradients, the nature of the chemokine signaling pathway, how Chemokines amplify immunologically-mediated disease, and whether disrupting chemokine signaling can treat or prevent disease. A systems biology approach to chemokine function in vivo will be highlighted and will extend to the regulation and interrelationship of the chemokine system with other regulatory systems in vivo. Directed cell migration is an essential process for normal development, homeostasis and the body's response to infection and cancer. Aberrant cell migration is a critical component of autoimmune and inflammatory diseases. Chemokines and chemokine receptors are the proteins in the body that control the migration of cells. A better understanding of how the chemokine system controls cell movement will lead to new ways of augmenting cell trafficking to fight of infectious diseases, cancer and improve vaccine efficacy as well as inhibit the pathologic recruitment of cells into tissue in autoimmune and inflammatory diseases.