Conference--Chemokines and Chemokine Receptors

会议--趋化因子和趋化因子受体

• 批准号: 7001945
• 负责人: ANDREW D LUSTER
• 金额: $ 1.05万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7001945
• 关键词: biological signal transduction; cell migration; chemokine; chemokine receptor; immune system; immunoregulation; meeting /conference /symposium; travel

Chemokines are chemotactic cytokines that induce the directed migration of cells by activating specific G protein-coupled receptors. This system of approximately 50 cytokines and approximately 20 receptors plays a particularly prominent role in development, homeostasis and activation of leukocytes in the mammalian immune system. Chemokines determine the nature of the tissue inflammatory response in a wide range of human diseases and represent attractive new therapeutic targets. Chemokines may also attract and stimulate non-immune cells, such as tumor cells, neurons and blood vessels. This meeting will address major unanswered questions in the chemokine field including how Chemokines regulate lymphoid development, how cells sense chemokine gradients, the nature of the chemokine signaling pathway, how Chemokines amplify immunologically-mediated disease, and whether disrupting chemokine signaling can treat or prevent disease. A systems biology approach to chemokine function in vivo will be highlighted and will extend to the regulation and interrelationship of the chemokine system with other regulatory systems in vivo. Directed cell migration is an essential process for normal development, homeostasis and the body's response to infection and cancer. Aberrant cell migration is a critical component of autoimmune and inflammatory diseases. Chemokines and chemokine receptors are the proteins in the body that control the migration of cells. A better understanding of how the chemokine system controls cell movement will lead to new ways of augmenting cell trafficking to fight of infectious diseases, cancer and improve vaccine efficacy as well as inhibit the pathologic recruitment of cells into tissue in autoimmune and inflammatory diseases.

趋化因子是通过激活特异性G蛋白偶联受体诱导细胞定向迁移的趋化性细胞因子。这种约50种细胞因子和约20种受体的系统在哺乳动物免疫系统中白细胞的发育、稳态和活化中起着特别突出的作用。 趋化因子决定了多种人类疾病中组织炎症反应的性质，并代表了有吸引力的新治疗靶点。趋化因子也可以吸引和刺激非免疫细胞，如肿瘤细胞，神经元和血管。本次会议将解决趋化因子领域的主要悬而未决的问题，包括趋化因子如何调节淋巴发育，细胞如何感知趋化因子梯度，趋化因子信号通路的性质，趋化因子如何放大免疫介导的疾病，以及破坏趋化因子信号传导是否可以治疗或预防疾病。一个系统生物学的方法，在体内的趋化因子功能将突出，并将扩展到在体内与其他监管系统的趋化因子系统的调节和相互关系。定向细胞 迁移是正常发育、体内平衡和身体对感染和癌症的反应的一个重要过程。异常细胞迁移是自身免疫性和炎症性疾病的关键组成部分。趋化因子和趋化因子受体是体内控制细胞迁移的蛋白质。更好地了解趋化因子系统如何控制细胞运动将导致增加细胞运输的新方法，以对抗传染病，癌症和提高疫苗效力，以及抑制自身免疫性和炎症性疾病中细胞向组织中的病理性募集。