2014 Chemotactic Cytokines Gordon Research Conference and Gordon Research Seminar

项目摘要 趋化因子，结构同源，功能不同的趋化细胞因子家族， 它们的同源经典信号和非典型非信号受体构成复杂的分子网络 几乎涉及人类健康和疾病的所有方面。2014年戈登研究会议（GRC） 趋化性细胞因子：在免疫和疾病中定位细胞是一个世界一流的会议， 来理解这些重要的分子。这将是我们的第11届趋化因子GRC，已举行的每 自1994年以来，趋化因子首次作为最大的细胞因子基因家族出现在舞台上， 人类基因组与本系列之前的每一次会议类似，Chemokine GRC 2014将汇集 来自广泛生物医学学科的科学家展示最新的未发表的研究成果 涵盖了趋化因子功能的各个方面，并提供了一个高质量的科学论坛来讨论它们的潜力 包括翻译到诊所。本次会议的议程将涵盖基础生物化学和 趋化因子的生物学方面与它们对白细胞迁移和移出的贡献有关， 免疫组织结构和功能，以及它们在炎症、感染、自身免疫和癌症中作用。在 此外，由于2012年第一届戈登趋化性细胞因子研究研讨会（GRS）的成功， 我们将在2014年再次为研究生和博士后水平的实验室科学家举办这一卫星会议 《趋化因子研究前沿》GRS提供了一个论坛，年轻的研究人员（例如，学生和 博士后研究员）可以展示他们的工作，并收到反馈意见，他们正在进行的研究项目，从 他们的同行和一个选定的高级专家小组。GRS将促进基层融合， 在趋化因子研究领域建立网络。要求NIH资金提供部分支持， 与会者登记。我们完全期待科学讨论，研究会谈，海报会议， 本次会议与会者之间的非正式互动将有助于推动我们的 了解趋化因子参与疾病发病机制的分子机制。这将奠定 为开发新的合作项目奠定基础，这将导致新的发现， 最终新的疗法和方法来治疗使人衰弱的疾病，包括炎性、感染性、 自身免疫性疾病和癌症。

PROJECT SUMMARY Chemokines, the structurally homologous, functionally distinct family of chemotactic cytokines together with their cognate classical signaling and atypical non-signaling receptors comprise a complex molecular network involved in nearly all aspects of human health and disease. The 2014 Gordon Research Conference (GRC) on Chemotactic Cytokines: Positioning Cells in Immunity and Disease is a world premier meeting devoted entirely to understanding these important molecules. This will be our 11th Chemokine GRC, which has been held every other year since 1994, when chemokines first burst onto the scene as the largest cytokine gene family in the human genome. Similar to each preceding conference in this series, Chemokine GRC 2014 will bring together scientists from a broad range of biomedical disciplines to showcase the latest unpublished research findings that cover all aspects of chemokine function and provide a high-quality scientific forum to discuss their potential implications, including translation to the clinic. The program of this meeting will cover basic biochemical and biological aspects of chemokines as related to their contributions to leukocyte migration and emigration, immune tissue organization and function, and their role in inflammation, infection, autoimmunity and cancer. In addition, due to the success of the first Gordon Research Seminar (GRS) on Chemotactic Cytokines in 2012, we will be having this satellite meeting for bench scientists at the graduate and postdoctoral level again in 2014 titled Frontiers in Chemokine Research. GRS provides a forum where young researchers (e.g., students and post-doctoral fellows) can present their work and receive feedback on their ongoing research projects from their peers and a selected panel of senior experts. GRS will promote grassroots level integration and networking within the field of chemokine research. NIH funding is requested to provide partial support for registration for participants. We fully anticipate that the scientific discussions, research talks, poster sessions, and informal interactions between the participants of this conference will contribute to advancing our understanding of molecular mechanisms of chemokine involvement in disease pathogenesis. This will lay the ground work for the development of new collaborative projects, which will lead to new discoveries and ultimately new therapies and approaches to treat debilitating human disease, including inflammatory, infectious and autoimmune diseases and cancer.