Conference on Roles of TGF-Beta in Disease Pathogenesis

TGF-β 在疾病发病机制中的作用会议

• 批准号: 6887127
• 负责人: Michael B Sporn
• 金额: $ 0.3万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-21 至 2006-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6887127
• 关键词: biological signal transduction; carcinogenesis; cellular immunity; fibrosis; meeting /conference /symposium; pathologic process; transforming growth factors; travel; wound healing

DESCRIPTION (provided by applicant): Elucidation of the signal transduction pathways of TGF-Beta has heralded an exciting new era enabling insights into molecular mechanisms of this multifunctional molecule in both normal adult physiology and disease pathogenesis, including especially wound healing, fibrosis, carcinogenesis and immune cell dysfunction. Characterization of the receptor kinases and identification of the Smad signaling pathway has identified new molecular targets and led to development of novel inhibitors of the pathway. Increased understanding of the biochemistry of TGF-Beta itself has also enabled developed of anti-ligand approaches. This is a particularly exciting time in the history of TGF-Beta as enough is known about its actions to have identified particular diseases in which it plays a role and finally, for the first time, pharmaceutical companies and biotech companies are developing new approaches to control this pathway with the goal of developing new therapies for wound healing, for fibrosis, and for treatment of cancer. Our goal for this conference is to bring together researchers focused on the basic biochemistry of TGF-Beta and on the use of animal models to elucidate its roles in disease pathogenesis and researchers from Biotech/Pharma who are developing these new drugs based on the TGF-Beta pathway. The hope is that this meeting will both enhance our insights into pathogenetic mechanisms of action of TGF-Beta in disease and provide novel therapeutic approaches for clinical treatment of disease.

描述（由申请人提供）：tgf - β信号转导途径的阐明预示着一个令人兴奋的新时代，使人们能够深入了解这种多功能分子在正常成人生理和疾病发病机制中的分子机制，特别是伤口愈合、纤维化、癌变和免疫细胞功能障碍。受体激酶的表征和Smad信号通路的鉴定已经确定了新的分子靶点，并导致了该通路的新型抑制剂的开发。对tgf - β本身生物化学的进一步了解也使抗配体方法得以发展。这是TGF-Beta历史上一个特别激动人心的时刻，因为我们对它的作用已经有了足够的了解，已经确定了它在其中发挥作用的特定疾病。最后，制药公司和生物技术公司第一次开始开发控制这一途径的新方法，目标是开发用于伤口愈合、纤维化和癌症治疗的新疗法。我们本次会议的目标是将专注于tgf - β基本生物化学和利用动物模型阐明其在疾病发病机制中的作用的研究人员以及正在开发基于tgf - β途径的新药的生物技术/制药研究人员聚集在一起。希望这次会议既能加深我们对tgf - β在疾病中作用的发病机制的认识，又能为疾病的临床治疗提供新的治疗方法。