Conference on Roles of TGF-Beta in Disease Pathogenesis

TGF-β 在疾病发病机制中的作用会议

• 批准号: 6887127
• 负责人: Michael B Sporn
• 金额: $ 0.3万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-21 至 2006-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6887127
• 关键词: biological signal transduction; carcinogenesis; cellular immunity; fibrosis; meeting /conference /symposium; pathologic process; transforming growth factors; travel; wound healing

DESCRIPTION (provided by applicant): Elucidation of the signal transduction pathways of TGF-Beta has heralded an exciting new era enabling insights into molecular mechanisms of this multifunctional molecule in both normal adult physiology and disease pathogenesis, including especially wound healing, fibrosis, carcinogenesis and immune cell dysfunction. Characterization of the receptor kinases and identification of the Smad signaling pathway has identified new molecular targets and led to development of novel inhibitors of the pathway. Increased understanding of the biochemistry of TGF-Beta itself has also enabled developed of anti-ligand approaches. This is a particularly exciting time in the history of TGF-Beta as enough is known about its actions to have identified particular diseases in which it plays a role and finally, for the first time, pharmaceutical companies and biotech companies are developing new approaches to control this pathway with the goal of developing new therapies for wound healing, for fibrosis, and for treatment of cancer. Our goal for this conference is to bring together researchers focused on the basic biochemistry of TGF-Beta and on the use of animal models to elucidate its roles in disease pathogenesis and researchers from Biotech/Pharma who are developing these new drugs based on the TGF-Beta pathway. The hope is that this meeting will both enhance our insights into pathogenetic mechanisms of action of TGF-Beta in disease and provide novel therapeutic approaches for clinical treatment of disease.

描述（由申请人提供）：TGF-β的信号转导途径的阐明，预示着令人兴奋的新时代，使得对这种多功能分子的分子机制在正常的成人生理和疾病发病机理中的分子机制，尤其是伤口愈合，纤维化愈合，纤维化，癌和免疫细胞生产力。 受体激酶的表征和SMAD信号通路的鉴定已确定了新的分子靶标，并导致了新型途径抑制剂的发展。 对TGF-β本身的生物化学的了解也使人发展了反配体方法。 在TGF-beta历史上，这是一个特别令人兴奋的时刻，因为它的行动已经足够了解，以确定其在其中发挥作用的特定疾病，最后，制药公司和生物技术公司首次开发了新方法来控制这种途径，目的是为了开发新的伤口愈合疗法来治疗伤口愈合，以治疗纤维化，以治疗癌症。 我们的这次会议的目标是将重点关注TGF-beta基本生物化学的研究人员汇集在一起​​，并使用动物模型来阐明其在疾病发病机理中的作用，以及基于TGF-beta途径开发这些新药物的生物技术/pharma的研究人员。 希望这次会议既可以增强我们对TGF-β在疾病中的致病作用机制的见解，又可以为疾病的临床治疗提供新颖的治疗方法。