Genetic and Caregiving Effects on Disordered Attachment

遗传和照顾对依恋障碍的影响

• 批准号: 6886788
• 负责人: KARLEN LYONS-RUTH
• 金额: $ 4.17万
• 依托单位: CAMBRIDGE HEALTH ALLIANCE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-15 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6886788
• 关键词: Europe; adolescence (12-20); behavioral genetics; child (0-11); child behavior; child psychology; child rearing; clinical research; cooperative study; dopamine; dopamine receptor; gene expression; genetic polymorphism; human data; human genetic material tag; human subject; longitudinal human study; low socioeconomic status; mental health epidemiology; mother child interaction; psychopathology; questionnaires; serotonin transporter; socioeconomics

DESCRIPTION (provided by applicant) Genetic and Caregiving Effects on Disordered Attachment Recent research has demonstrated that both childhood behavior problems and adolescent psychopathology are predicted by disorganized attachment behavior in infancy. Disorganized infant attachment behavior has been further related to aspects of maternal caregiving in recent studies. Two recent reports from Hungarian scientists Sasvari-Szekely and Gervai have also demonstrated a genetic contribution to disorganized attachment behavior related to polymorphisms of the dopamine D4 receptor gene (DRD4). Because animal models have documented both genetic and non-genetic (caregiving) contributions to neurobiologic systems related to human psychopathology (HPA axis activity and biogenic amine function), human studies are now needed that can evaluate relative contributions of both genetic and caregiving contributions to processes related to child and adolescent psychopathology. The first aim of this study is to extend the data and methods of NIH grant R01 MH 062030, Psychopathology and Controlling Behavior in Adolescence to include non-invasive collection of genetic samples. These samples will be analyzed for the contribution of both DRD4 and serotonin transporter 5-HTT risk alleles to infant disorganization and later related psychopathology in the U.S. socially at-risk longitudinal cohort being studied under this parent grant. The second aim of the study is to extend genetic methods to the study of maternal caregiving behavior. Maternal behavioral assessments already collected for the U.S. sample in infancy will also be collected for the low-risk Budapest Infant-Parent study sample, and the contribution of the DRD4 and 5-HTT candidate genes to maternal frightened, frightening, or other atypical behavior will be assessed in both samples. The third aim of this study is to evaluate additive and interactive statistical models of the relative contributions of genetic and nongenetic components of maternal behavior and infant disorganization to later psychopathology in the U.S. longitudinal cohort. This extension of the parent grant methodology should contribute substantially to our understanding of the long-term developmental trajectories that culminate in psychopathology. It is essential to seek a thorough understanding of the developmental pathways through which such behavior develops over time to implement prevention or treatment programs for reducing adolescent antisocial behavior and psychopathology. This research will be carried out primarily in Budapest, Hungary, at the laboratories of Drs. Sasvari-Szekely and Gervai as an extension of Dr. Lyons-Ruth's U.S. grant, NIH R01 MH 062030.

描述（由申请人提供） 遗传和照顾对依恋障碍的影响 最近的研究表明，童年行为问题和青少年精神病理学都是由婴儿期混乱的依恋行为预测的。最近的研究表明，婴儿依恋行为紊乱与母亲护理方面进一步相关。匈牙利科学家 Sasvari-Szekely 和 Gervai 最近的两份报告也证明了与多巴胺 D4 受体基因 (DRD4) 多态性相关的紊乱依恋行为的遗传因素。由于动物模型已经记录了遗传和非遗传（照顾）对与人类精神病理学相关的神经生物学系统（HPA轴活动和生物胺功能）的贡献，因此现在需要人类研究来评估遗传和照顾对与儿童和青少年精神病理学相关过程的相对贡献。 本研究的首要目的是扩展 NIH 拨款 R01 MH 062030“青春期精神病理学和控制行为”的数据和方法，以包括基因样本的非侵入性收集。这些样本将被分析，以了解 DRD4 和血清素转运蛋白 5-HTT 风险等位基因对婴儿解体的贡献，以及随后在美国社会风险纵向队列中相关的精神病理学，该队列正在根据这项家长资助进行研究。 该研究的第二个目的是将遗传方法扩展到母亲护理行为的研究中。已经为美国样本收集的婴儿期母亲行为评估也将针对低风险布达佩斯婴儿父母研究样本收集，并且将在这两个样本中评估 DRD4 和 5-HTT 候选基因对母亲惊恐、恐惧或其他非典型行为的贡献。 本研究的第三个目的是评估母亲行为和婴儿混乱的遗传和非遗传成分对美国纵向队列后来的精神病理学的相对贡献的加性和交互统计模型。 家长资助方法的这种扩展应该大大有助于我们理解最终形成精神病理学的长期发展轨迹。必须彻底了解此类行为随着时间的推移而发展的发展途径，以实施减少青少年反社会行为和精神病理学的预防或治疗计划。 这项研究将主要在匈牙利布达佩斯博士的实验室进行。 Sasvari-Szekely 和 Gervai 作为 Lyons-Ruth 博士的美国资助 (NIH R01 MH 062030) 的延伸。