Genetic and Caregiving Effects on Disordered Attachment

遗传和照顾对依恋障碍的影响

• 批准号: 6738171
• 负责人: KARLEN LYONS-RUTH
• 金额: $ 4.16万
• 依托单位: CAMBRIDGE HEALTH ALLIANCE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-15 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6738171
• 关键词: Europe; adolescence (12-20); behavioral genetics; child (0-11); child behavior; child psychology; child rearing; clinical research; cooperative study; dopamine; dopamine receptor; gene expression; genetic polymorphism; human data; human genetic material tag; human subject; longitudinal human study; low socioeconomic status; mental health epidemiology; mother child interaction; psychopathology; questionnaires; serotonin transporter; socioeconomics

DESCRIPTION (provided by applicant) Genetic and Caregiving Effects on Disordered Attachment Recent research has demonstrated that both childhood behavior problems and adolescent psychopathology are predicted by disorganized attachment behavior in infancy. Disorganized infant attachment behavior has been further related to aspects of maternal caregiving in recent studies. Two recent reports from Hungarian scientists Sasvari-Szekely and Gervai have also demonstrated a genetic contribution to disorganized attachment behavior related to polymorphisms of the dopamine D4 receptor gene (DRD4). Because animal models have documented both genetic and non-genetic (caregiving) contributions to neurobiologic systems related to human psychopathology (HPA axis activity and biogenic amine function), human studies are now needed that can evaluate relative contributions of both genetic and caregiving contributions to processes related to child and adolescent psychopathology. The first aim of this study is to extend the data and methods of NIH grant R01 MH 062030, Psychopathology and Controlling Behavior in Adolescence to include non-invasive collection of genetic samples. These samples will be analyzed for the contribution of both DRD4 and serotonin transporter 5-HTT risk alleles to infant disorganization and later related psychopathology in the U.S. socially at-risk longitudinal cohort being studied under this parent grant. The second aim of the study is to extend genetic methods to the study of maternal caregiving behavior. Maternal behavioral assessments already collected for the U.S. sample in infancy will also be collected for the low-risk Budapest Infant-Parent study sample, and the contribution of the DRD4 and 5-HTT candidate genes to maternal frightened, frightening, or other atypical behavior will be assessed in both samples. The third aim of this study is to evaluate additive and interactive statistical models of the relative contributions of genetic and nongenetic components of maternal behavior and infant disorganization to later psychopathology in the U.S. longitudinal cohort. This extension of the parent grant methodology should contribute substantially to our understanding of the long-term developmental trajectories that culminate in psychopathology. It is essential to seek a thorough understanding of the developmental pathways through which such behavior develops over time to implement prevention or treatment programs for reducing adolescent antisocial behavior and psychopathology. This research will be carried out primarily in Budapest, Hungary, at the laboratories of Drs. Sasvari-Szekely and Gervai as an extension of Dr. Lyons-Ruth's U.S. grant, NIH R01 MH 062030.

描述（由申请人提供） 遗传和照顾对依恋障碍的影响 最近的研究表明，儿童期行为问题和青少年精神病理学都是由婴儿期的无组织依恋行为预测的。在最近的研究中，混乱的婴儿依恋行为进一步与母亲的依恋行为有关。匈牙利科学家Sasvari-Szekely和Gervai最近的两份报告也证明了与多巴胺D4受体基因（DRD 4）多态性相关的混乱依恋行为的遗传贡献。由于动物模型已经记录了遗传和非遗传（hepatocyte）的贡献与人类精神病理学（HPA轴活动和生物胺功能）的神经生物学系统，人类研究，现在需要可以评估的相对贡献的遗传和hepatocyte的贡献与儿童和青少年的精神病理学的过程。 本研究的第一个目的是扩展美国国立卫生研究院（NIH）资助的R 01 MH 062030，青少年精神病理学和控制行为的数据和方法，包括非侵入性的遗传样本收集。将分析这些样本中DRD 4和5-羟色胺转运体5-HTT风险等位基因对美国社会风险纵向队列中婴儿混乱和后来相关精神病理学的贡献。 本研究的第二个目的是将遗传学方法扩展到对母亲生育行为的研究中。已经收集的美国婴儿期样本的母亲行为评估也将收集低风险布达佩斯婴儿-父母研究样本，并将在两个样本中评估DRD 4和5-HTT候选基因对母亲惊恐、惊吓或其他非典型行为的贡献。 本研究的第三个目的是评估美国纵向队列中遗传和非遗传成分对母亲行为和婴儿混乱对后期精神病理学的相对贡献的加性和交互式统计模型。 这种家长资助方法的扩展应该大大有助于我们对最终导致精神病理学的长期发展轨迹的理解。这是至关重要的，以寻求通过这种行为的发展途径，随着时间的推移，以实施预防或治疗计划，减少青少年反社会行为和精神病理学的发展透彻的理解。 这项研究将主要在匈牙利布达佩斯的Sasvari-Szekely和Gervai博士的实验室进行，作为Lyons-Ruth博士美国基金NIH R 01 MH 062030的延伸。