Viruses and Autoimmunity POI

病毒和自身免疫 POI

• 批准号: 6883924
• 负责人: Matthias G. Von Herrath
• 金额: $ 110.23万
• 依托单位: LA JOLLA INSTITUTE FOR IMMUNOLOGY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6883924
• 关键词: autoimmunity; genetically modified animals; insulin dependent diabetes mellitus; laboratory mouse; multiple sclerosis; virus infection mechanism

Our goal here is to understand how several candidate viral infections enhance autoimmune disease in multiple sclerosis (EAE) and diabetes disease models (von Herrath and Fujinami). The novel aspects addressed by this PPG are: 1. The hypothesis that viral infections will be able to provide a 'fertile field' for autoaggressive lymphocytes or enhance already pre-existing but sub-clinical autoimmune processes. 2. The detailed mechanistic analysis involving mimicry as well as bystander activation, in particular the understanding of the basic mechanistic aspects of virally triggered presentation of autoantigens and activation of autoaggressive lymphocytes from the APC/immuno-proteasome side (Whitton). The emerging findings will be useful in pursuing the link between viruses and autoimmunity in humans in a more directional/mechanistic way.

我们的目标是了解几种候选病毒感染如何增强多发性硬化症（EAE）和糖尿病模型（von Herrath和Fujinami）中的自身免疫性疾病。本PPG解决的新方面是： 1.假设病毒感染将能够为自身攻击性淋巴细胞提供“肥沃的土地”或增强已经存在但亚临床的自身免疫过程。 2.详细的机制分析涉及模仿以及旁观者激活，特别是对病毒触发的自身抗原呈递和APC/免疫蛋白酶体侧自身攻击性淋巴细胞激活的基本机制方面的理解（惠顿）。 这些新发现将有助于以更有方向性/机制性的方式探索病毒与人类自身免疫之间的联系。