Identification of D-serine-related gene and elucidation of etiology of schizophrenia using genetically modified animals

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We have investigated the identification of schizophrenia-related genes and the elucidation of genetically modified animals as schizophrenia-model animals using genetically modified animals. Using DNA microarrays, a variety of genes was increased and decreased. A stimulant exposure resulted in the increase of abnormal behaviors in the genetically modified animals compared to the wild mice. These data indicated that the genetically modified animals could be the model animals of schizophrenia.