ATTENTIONAL PROCESSING OF TEMPORAL INFORMATION

描述（由申请人提供）：基本行为过程，如 联想学习、速率计算和决策制定关键依赖于 估计和再现秒至分钟范围内的时间间隔 （间隔定时）。大多数时机理论的基本假设之一是 受试者能够容易地从输入刺激中抽象出 信息，并根据这一线索调整他们的行为，无论 非时间属性的真实的定时事件。相反，证据表明， 动物和人类的时间都对时间的属性非常敏感。 定时信号，从而支持“注意力开关/门”的概念。 间隔计时机制。 本研究的目的是研究注意加工的时间效应 秒到分钟范围内的信息（间隔计时）， 多层次、行为、神经药理学和计算方法。 行为上，研究者将研究一种新开发的间隔计时 程序表明，从事时间线索的注意处理。在这 程序，研究人员建议评估的影响， 时间刺激的特性和时间记忆。从药理学上讲， 研究者建议将时钟效应和注意力分离开来， 特异性多巴胺激动剂和拮抗剂对间隔时间的影响。我们 我还建议研究参与注意的神经基质， 定时开关/门控机构。在计算方面，研究人员建议 建立了一个注意力开关/门机制的模型， 为了解决行为和药理学操作对 时间信息的注意加工。 这些研究将为当前的计时模型，时间感知， 间隔时间的神经药理学它们将提供新的手段， 理解注意力因素对复杂认知机制的影响 这需要时间处理。它们将有助于阐明 时间信息注意加工的神经基础

DESCRIPTION (provided by applicant): Fundamental behavioral processes such as associative learning, rate calculation and decision making crucially rely on estimation and reproduction of time intervals in the seconds-to-minutes range (interval timing). One of the underlying assumptions of most timing theories is that subjects are able to readily abstract from the input stimulus the temporal information, and to tune their behavior according to this cue, irrespective of non-temporal properties the real timed event. In contrast, evidence suggests that both animal and human timing is highly sensitive to properties of the timed signal thus supporting the notion of an "attentional switch/gate" interval timing mechanism. The objective of this proposal is to study attentional processing of temporal information in the seconds-to-minutes range (interval timing) using a multi-level, behavioral, neuropharmacological, and computational approach. Behaviorally, the investigator will study a newly developed interval timing procedure shown to engage attentional processing of temporal cues. Within this procedure, the investigator proposes to evaluate the impact of the characteristics of stimuli on timing and memory for timing. Pharmacologically, the investigator proposes to dissociate the clock effects and attentional effects of specific dopamine agonists and antagonists on interval timing. We also propose to investigate the neural substrates involved in the attentional switch/gate mechanism of timing. Computationally, the investigator proposes to develop a model of the attentional switch/gate mechanism of interval timing in order to address the effect of behavioral and pharmacological manipulations on attentional processing of temporal information. The studies will inform current models of timing, time perception, and neuropharmacology of interval timing. They will provide new means for understanding the impact of attentional factors on complex cognitive mechanisms that require temporal processing. They will help elucidate the pharmacological and neural basis of attentional processing of temporal information