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Arousal and Timekeeping in a Mouse Model of Parkinsonism

帕金森病小鼠模型的唤醒和计时

基本信息

批准号：
10437525
负责人：
CATALIN V. BUHUSI
金额：
$ 43.8万
依托单位：
UTAH STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10437525
关键词：
Aging Agonist Alzheimer&apos s Disease Animal Model Arousal Attention Behavior Behavioral Behavioral Genetics Biochemical C57BL/6 Mouse Clinical Treatment Cognition Cognitive Cognitive deficits Corpus striatum structure Decision Making Diurnal Rhythm Dopamine Emotional Executive Dysfunction Generations Goals Huntington Disease Hypothalamic structure Impaired cognition Impairment Infusion procedures Lateral Lesion Medial Mental Depression Methods Modeling Motor Motor Activity Movement Movement Disorders Mus Nerve Degeneration Neurons Neurotransmitters Norepinephrine Outcome Parkinson Disease Parkinsonian Disorders Pathway interactions Patients Performance Pharmaceutical Preparations Pharmacology Prefrontal Cortex Process Production Protocols documentation Reproduction Response to stimulus physiology Role Sleep Symptoms Time Wakefulness alertness behavioral response classical conditioning cognitive control cognitive enhancement cognitive function cognitive performance executive function frontal lobe glial cell-line derived neurotrophic factor hypocretin improved locus ceruleus structure migration motivated behavior motor control motor deficit motor impairment mouse model neural circuit neurobiological mechanism neuronal circuitry neuropsychiatric disorder noradrenergic novel object recognition receptor response sensory input shift work stem treatment strategy vigilance way finding

项目摘要

PROJECT SUMMARY / ABSTRACT Movement disorders, such as Parkinson’s Disease (PD) and Huntington’s Disease, are characterized by drastic impairments in planning and executing movement, as well as cognitive deficits, some of which stem from deficits in estimating durations. Estimation and reproduction of durations in the seconds-to-minutes range are critical for fundamental processes such as associative learning, planned motor responses and decision-making. This project will explore neurobiological mechanisms involved in the estimation and reproduction of durations to evaluate timed motor response deficits in mouse models of PD. We will investigate the role of arousal, and the involvement of a novel neurotransmitter, orexin, in alterations of timed response selection using a newly developed model of timed response selection deficits in PD. We will also evaluate pharmacological approaches to rescue motor timing deficits. The project will enhance our understanding of neuronal processes involved in cognitive and motor control deficits in movement disorders, and will help develop new treatment strategies in animal models, with possible subsequent impact on clinical treatments.

项目摘要/摘要