Regulation of juvenile hormone titers in mosquitoes
蚊子保幼激素滴度的调节
基本信息
- 批准号:6984356
- 负责人:
- 金额:$ 37.77万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-07-01 至 2010-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): Mosquito-transmitted parasitic diseases are among the major causes of mortality and morbidity in the world. Recent dramatic increases in the incidence of mosquito-borne diseases, like malaria and dengue fever, and the wide-spread resistance of mosquitoes to insecticides underscores the need for new approaches to insect control based on mosquito- specific agents. The discovery of such mosquito-specific control agents depends on basic research on the biology of mosquitoes. Juvenile hormone (JH) is a major hormonal regulator in insects. In the female mosquito, JH signals the completion of the ecdysis to the adult stage, and initiates reproductive processes. JH titer is essentially determined by the rate at which the corpora allata (CA) synthesizes JH. The rate of CA activity is, in turn, regulated by allato-regulatory peptides that exert either allatostatic (inhibitory) or allatotropic (stimulatory) activities. During the first three years of this project we have described that allatotropin (AT) stimulates and allatostatin-C (AS-C) inhibits JH synthesis, that nutrients accumulated during the larval stages regulate CA activity, and also performed the first genomic analysis of an insect endocrine gland. Based on this work we propose that AT and AS released by the brain are essential for the activation and modulation of JH synthesis in adult female mosquitoes. The synthesis and release of these peptides is connected to nutritional signals. JH is therefore an important part of a transduction mechanism that connects changes in the nutritional status with activation of specific physiological events during reproduction. The goal of this project is to understand how peptides regulate the synthesis of JH in mosquitoes. The ultimate aim of this project is to reveal how changes in the mosquito's nutritional status are assessed and how this information is transduced to the CA. In order to test this model, in this application we propose to: 1. Investigate the mechanisms of control of JH synthesis by AT and AS-C. 2. Study the nutritional regulation of synthesis and release of AT and AS-C in the brain. Understanding the molecular basis of the physiological action of neuro-peptides will guide us in designing new and affordable agents for vector control.
描述(由申请人提供):蚊子传播的寄生虫病是世界上死亡和发病的主要原因。最近蚊子传播的疾病(如疟疾和登革热)的发病率急剧增加,以及蚊子对杀虫剂的广泛抗性强调了对基于蚊子特异性试剂的昆虫控制新方法的需要。这种蚊子特异性控制剂的发现取决于对蚊子生物学的基础研究。保幼激素(JH)是昆虫体内主要的激素调节剂。在雌性蚊子中,JH发出完成蜕皮到成虫阶段的信号,并启动生殖过程。JH滴度基本上由咽侧体(CA)合成JH的速率决定。CA活性的速率反过来又受到allato-regulatory肽的调节,allato-regulatory肽发挥allatostatic(抑制性)或allatotropic(刺激性)活性。在这个项目的前三年,我们已经描述了,allatotropin(AT)刺激和allatostatin-C(AS-C)抑制JH合成,在幼虫阶段积累的营养物质调节CA活性,也进行了第一个昆虫内分泌腺的基因组分析。基于这项工作,我们提出,AT和AS释放的大脑是必不可少的激活和调制的JH合成在成年雌性蚊子。这些肽的合成和释放与营养信号有关。因此,JH是一种转导机制的重要组成部分,该机制将营养状态的变化与生殖过程中特定生理事件的激活联系起来。该项目的目标是了解肽如何调节蚊子中JH的合成。该项目的最终目的是揭示如何评估蚊子营养状况的变化以及如何将这些信息传递到CA。为了检验该模型,在本申请中我们提出:1.探讨AT和AS-C调控JH合成的机制。2.研究脑内AT和AS-C合成与释放的营养调节。了解神经肽的生理作用的分子基础将指导我们设计新的和负担得起的媒介控制剂。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Fernando Gabriel. Noriega其他文献
Fernando Gabriel. Noriega的其他文献
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{{ truncateString('Fernando Gabriel. Noriega', 18)}}的其他基金
How can mosquitoes develop and reproduce in the complete absence of juvenile hormone?
在完全没有保幼激素的情况下,蚊子如何发育和繁殖?
- 批准号:
10410633 - 财政年份:2022
- 资助金额:
$ 37.77万 - 项目类别:
Regulation of juvenile hormone titers in mosquitoes
蚊子保幼激素滴度的调节
- 批准号:
8097616 - 财政年份:2010
- 资助金额:
$ 37.77万 - 项目类别:
Regulation of Juvenile Hormone levels in mosquitos
蚊子保幼激素水平的调节
- 批准号:
6632099 - 财政年份:2001
- 资助金额:
$ 37.77万 - 项目类别:
Regulation of juvenile hormone titers in mosquitoes
蚊子保幼激素滴度的调节
- 批准号:
8278043 - 财政年份:2001
- 资助金额:
$ 37.77万 - 项目类别:
Regulation of juvenile hormone titers in mosquitoes
蚊子保幼激素滴度的调节
- 批准号:
7212241 - 财政年份:2001
- 资助金额:
$ 37.77万 - 项目类别:
Regulation of juvenile hormone titers in mosquitoes
蚊子保幼激素滴度的调节
- 批准号:
9090052 - 财政年份:2001
- 资助金额:
$ 37.77万 - 项目类别:
Regulation of Juvenile Hormone levels in mosquitos
蚊子保幼激素水平的调节
- 批准号:
6382658 - 财政年份:2001
- 资助金额:
$ 37.77万 - 项目类别:
Regulation of juvenile hormone titers in mosquitoes
蚊子保幼激素滴度的调节
- 批准号:
8655511 - 财政年份:2001
- 资助金额:
$ 37.77万 - 项目类别:
Regulation of juvenile hormone titers in mosquitoes
蚊子保幼激素滴度的调节
- 批准号:
8982645 - 财政年份:2001
- 资助金额:
$ 37.77万 - 项目类别:
Regulation of Juvenile Hormone levels in mosquitos
蚊子保幼激素水平的调节
- 批准号:
6866968 - 财政年份:2001
- 资助金额:
$ 37.77万 - 项目类别: