In Vivo Optical Detection of Dysplasia in Esophagus

食管发育不良的体内光学检测

• 批准号: 6869380
• 负责人: Lev T Perelman
• 金额: $ 42.87万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-05 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6869380
• 关键词: Barretts esophagus; adenocarcinoma; bioimaging /biomedical imaging; biomarker; biomedical equipment development; clinical research; computer program /software; diagnosis design /evaluation; early diagnosis; endoscopy; gastrointestinal imaging /visualization; histopathology; human subject; light scattering; mathematical model; neoplasm /cancer diagnosis; optics; tissue /cell culture

DESCRIPTION (provided by applicant): The purpose of this program is to provide the gastroenterologist with a diagnostic screening tool which will enable him to rapidly survey the region of Barrett's esophagus (BE) in a patient with this disease, and allow him to determine with high probability and in real-time, regions of dysplasia and carcinoma. It will be able to distinguish between the categories of adenocarcinoma, high-grade dysplasia, low-grade dysplasia, indefinite for dysplasia and non-dysplastic BE. It will be able to perform measurements of the full length of the esophagus in about ten minutes and provide the information in real time. Suspicious areas can then be biopsied and the diagnosis verified. This approach is vastly superior to the present strategies of performing either systematic or random biopsies. Thus it will provide a powerful tool for screening the large population of Barrett's esophagus patients for early precancerous changes. This instrument will be based on the technique of light scattering spectroscopy (LSS), which has been demonstrated in a proof-of-principle study to be able to perform such measurements in the epithelial tissue of five different organs, including BE. The advantages of the proposed technique are that it greatly simplifies the time and labor involved in performing screening and obtaining diagnoses, will cause less patient discomfort, require fewer biopsies, and it can help the pathologist to base his diagnosis on uniform quantitative criteria, making the diagnosis more consistent. Because of these advantages, it should vastly improve the probability of detecting potential malignancies in the early stages, when cures are possible, and it should be highly cost effective. Since tissue is not necessarily removed, it makes possible progression studies. Such studies may determine accurate predicative factors for the outcome of the disease, and thus simplify the decision in the choice of treatment.

描述（由申请人提供）：该程序的目的是为胃肠病医生提供诊断筛查工具，这将使他能够在患有这种疾病的患者中迅速调查Barrett的食管（BE）地区，并让他以很高的可能性和实时的生命值和癌症地区确定。它将能够区分腺癌，高级发育不良，低度发育异常，无限期性发育不良和非塑性BE的类别。它将能够在大约十分钟内对食道的全长进行测量，并实时提供信息。然后可以进行可疑区域进行活检并验证诊断。这种方法优于执行系统或随机活检的当前策略。因此，它将提供一个强大的工具，用于筛选大量的巴雷特食道患者，以造成早期癌前变化。 该仪器将基于光散射光谱法（LSS）的技术，该技术在原则研究中已证明，能够在包括BE在内的五个不同器官的上皮组织中进行此类测量。该提出的技术的优点在于，它极大地简化了进行筛查和获得诊断的时间和劳动，将导致患者不适，需要更少的活检，并且可以帮助病理学家以统一的定量标准将其诊断为基础，从而使诊断更加一致。由于具有这些优势，它应该大大提高在可能的早期阶段检测潜在恶性肿瘤的可能性，并且在可能的情况下应该具有很高的成本效益。由于不一定要去除组织，因此可能会进行进展研究。这样的研究可能会确定疾病结果的准确谓语因素，从而简化治疗选择中的决策。